ArticleThe American journal of pathology2004
The 14-3-3 protein epsilon isoform expressed in reactive astrocytes in demyelinating lesions of multiple sclerosis binds to vimentin and glial fibrillary acidic protein in cultured human astrocytes.
Article in The American journal of pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens and damage molecular patterns.Cellular & molecular immunology · 2025Review
- Demyelination-induced glutamatergic imbalance mediates hippocampal Hyperexcitability.Neurobiology of disease · 2025Article
- Mapping Molecular Pathways of Multiple Sclerosis: A Gene Prioritization and Network Analysis of White Matter Pathology Transcriptomics.Annals of neurology · 2025Article
- Multiomic Evidence for a Unified Model of Alzheimer's Disease Etiology Linking Microglial Flux Capacity and Astrocyte-Neuron Metabolic Breakdown.bioRxiv : the preprint server for biology · 2025Article
- Vimentin as a potential target for diverse nervous system diseases.Neural regeneration research · 2023Review
- Two Metabolic Fuels, Glucose and Lactate, Differentially Modulate Exocytotic Glutamate Release from Cultured Astrocytes.Neurochemical research · 2021Article
- The construction of EpCAM/vimentin-PLGA/lipid immunomagnetic microspheres and the isolation of circulating tumor cells from lung cancer.International journal of clinical and experimental pathology · 2018Article
- Two-pore Domain Potassium Channels in Astrocytes.Experimental neurobiology · 2016Review
- Article
- Role of glial 14-3-3 gamma protein in autoimmune demyelination.Journal of neuroinflammation · 2015Article
- Activation of NF-κB signalling by fusicoccin-induced dimerization.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- DNA-PK target identification reveals novel links between DNA repair signaling and cytoskeletal regulation.PloS one · 2013Article
- Neuroprotective function of 14-3-3 proteins in neurodegeneration.BioMed research international · 2013Review
- Article
- Microwave and magnetic (M(2) ) proteomics of the experimental autoimmune encephalomyelitis animal model of multiple sclerosis.Electrophoresis · 2012Article
- Roles of vimentin and 14-3-3 zeta/delta in the inhibitory effects of heparin on PC-3M cell proliferation and B16-F10-luc-G5 cells metastasis.Acta pharmacologica Sinica · 2012Article
- Article
- Are cerebrospinal fluid biomarkers useful in predicting the prognosis of multiple sclerosis patients?International journal of molecular sciences · 2011Review
- Article
- Cerebrospinal fluid and blood biomarkers of neuroaxonal damage in multiple sclerosis.Multiple sclerosis international · 2011Article
Corrections and comments
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The 14-3-3 protein family consists of acidic 30-kd proteins expressed at high levels in neurons of the central nervous system. Seven isoforms form a dimeric complex that acts as a molecular chaperone that interacts with key signaling components. Recent studies indicated that the 14-3-3 protein identified in the cerebrospinal fluid of various neurological diseases including multiple sclerosis (MS) is a marker for extensive brain destruction. However, it remains unknown whether the 14-3-3 protein plays an active role in the pathological process of MS. To investigate the differential expression of seven 14-3-3 isoforms in MS lesions, brain tissues of four progressive cases were immunolabeled with a panel of isoform-specific antibodies. Reactive astrocytes in chronic demyelinating lesions intensely expressed beta, epsilon, zeta, eta, and sigma isoforms, among which the epsilon isoform is a highly specific marker for reactive astrocytes. Furthermore, protein overlay, mass spectrometry, immunoprecipitation, and double-immunolabeling analysis showed that the 14-3-3 protein interacts with both vimentin and glial fibrillary acidic protein in cultured human astrocytes. These results suggest that the 14-3-3 protein plays an organizing role in the intermediate filament network in reactive astrocytes at the site of demyelinating lesions in MS.
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