ArticleThe American journal of pathology2004
Molecular classification of parathyroid neoplasia by gene expression profiling.
Article in The American journal of pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Primary hyperparathyroidism: predictors of sporadic multi-gland disease.Endocrine connections · 2024Review
- Molecular Genetic Aspects of Sporadic Multiglandular Primary Hyperparathyroidism.Physiological research · 2023Review
- Comprehensive Transcriptomic Analysis Reveals the Role of the Immune Checkpoint HLA-G Molecule in Cancers.Frontiers in immunology · 2021Article
- Overexpressed gene signature of EPH receptor A/B family in cancer patients-comprehensive analyses from the public high-throughput database.International journal of clinical and experimental pathology · 2020Article
- Transcriptional profiling reveals distinct classes of parathyroid tumors in PHPT.Endocrine-related cancer · 2018Article
- Diagnosis, management, histology and genetics of sporadic primary hyperparathyroidism: old knowledge with new tricks.Endocrine connections · 2018Review
- Cancer-type dependent expression of CK2 transcripts.PloS one · 2017Article
- Diagnosis and management of parathyroid cancer.Nature reviews. Endocrinology · 2012Review
- The emerging role of CXCL10 in cancer (Review).Oncology letters · 2011Article
- Regulator of G protein signaling 5 is highly expressed in parathyroid tumors and inhibits signaling by the calcium-sensing receptor.Molecular endocrinology (Baltimore, Md.) · 2011Article
- Impaired OXPHOS complex III in breast cancer.PloS one · 2011Article
- Molecular genetics of parathyroid disease.World journal of surgery · 2009Review
- Clustering algorithms: on learning, validation, performance, and applications to genomics.Current genomics · 2009Article
- Familial isolated hyperparathyroidism is linked to a 1.7 Mb region on chromosome 2p13.3-14.Journal of medical genetics · 2006Article
- External quality assessment of tumour marker analysis: state of the art and consequences for estimating diagnostic sensitivity and specificity.German medical science : GMS e-journal · 2005Article
- Association Between hsa-miR-30e Polymorphisms and Sporadic Primary Hyperparathyroidism Risk.In vivo (Athens, Greece)Article
- Proteomics Analysis of Tissue Samples Reveals Changes in Mitochondrial Protein Levels in Parathyroid Hyperplasia over Adenoma.Cancer genomics & proteomicsArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current classification of sporadic parathyroid neoplasia, specifically the distinction of adenoma from multiple gland neoplasia (double adenoma and nonfamilial primary hyperplasia) is problematic and results in a relatively high rate of clinical error. Oligonucleotide microarrays (Affymetrix U133A) were used to evaluate parathyroid samples from 61 patients; 35 adenomas, 10 nonfamilial multiple gland neoplasia, 3 familial primary hyperplasia, 8 renal-induced hyperplasia, and 5 from patients without parathyroid disease (normals). A multiclass comparison using supervised clustering identified distinct gene signatures for each class of parathyroid samples. We developed a predictor model that correctly identified 34 of 35 cases of adenoma, 9 of 10 cases of nonfamilial multiple gland neoplasia, and identified a minimum set of 11 genes for the distinction of adenoma versus multiple gland neoplasia. All methods of unsupervised clustering showed two related but different types of parathyroid adenomas that we have arbitrarily designated as type 1 and type 2 adenomas. Multiple gland parathyroid neoplasia, which represents either synchronous or asynchronous autonomous growth in two, three, or all four parathyroid glands, is a distinct molecular entity and does not represent the molecular pathogenesis of adenoma occurring in multiple glands.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.