ArticleThe American journal of pathology2004
Cytogenetic alterations affecting BCL6 are predominantly found in follicular lymphomas grade 3B with a diffuse large B-cell component.
Article in The American journal of pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 130 citations in OpenAlex.
- Whole-genome sequencing reveals three follicular lymphoma subtypes with distinct cell of origin and patient outcomes.Cell reports. Medicine · 2025Article
- Subsets of follicular lymphoma 3B have divergent outcomes: results from the prospective multicenter MER and LEO cohorts.Blood cancer journal · 2025Article
- The clinical and molecular taxonomy of t(14;18)-negative follicular lymphomas.Blood advances · 2023Article
- Review
- Prognostic impact of nutritional and inflammation-based risk scores in follicular lymphoma in the era of anti-CD20 targeted treatment strategies.Journal of cancer research and clinical oncology · 2022Article
- Treatment of indolent lymphoma.Blood research · 2022Review
- Common Presentation of an Uncommon Small Intestinal Lymphoma: A Rare Case Entity.Gastrointestinal tumors · 2021Article
- Unraveling Tumor Heterogeneity in an Apparently Monolithic Disease: BCL2 and Other Players in the Genetic Landscape of Nodal Follicular Lymphoma.Frontiers in medicine · 2019Review
- Gene expression profiling reveals a close relationship between follicular lymphoma grade 3A and 3B, but distinct profiles of follicular lymphoma grade 1 and 2.Haematologica · 2018Article
- Bendamustine plus Rituximab Versus R-CHOP as First-Line Treatment for Patients with Follicular Lymphoma Grade 3A: Evidence from a Multicenter, Retrospective Study.The oncologist · 2018Article
- The Challenges of Precision Medicine and New Advances in Molecular Diagnostic Testing in Hematolymphoid Malignancies: Impact on the VHA.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2017Article
- miR-31 and miR-17-5p levels change during transformation of follicular lymphoma.Human pathology · 2016Article
- CD5-positive follicular lymphoma: clinicopathologic correlations and outcome in 88 cases.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015Article
- Immunophenotypic features and t(14;18) (q32;q21) translocation of Chinese follicular lymphomas helps to distinguish subgroups.Diagnostic pathology · 2013Article
- Follicular lymphoma grade 3B: is it a real disease?Haematologica · 2011Article
- Follicular lymphoma grade 3B is a distinct neoplasm according to cytogenetic and immunohistochemical profiles.Haematologica · 2011Article
- Transformation of follicular lymphoma.Best practice & research. Clinical haematology · 2011Review
- Follicular lymphomas with plasmacytic differentiation include two subtypes.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2010Article
- t(14;18)-negative follicular lymphomas are associated with a high frequency of BCL6 rearrangement at the alternative breakpoint region.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2009Article
- Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, classical banding cytogenetic studies suggested that follicular lymphomas (FLs) grade 3 with preserved maturation to centrocytes (FL3A) are closely related to FL grades 1 and 2 and frequently harbor the t(14;18), whereas FL grade 3B, consisting of centroblasts exclusively, do frequently show 3q27 alterations. To clarify the prevalence of BCL6 and BCL2 rearrangements in FL and diffuse large B-cell lymphomas (DLBLs), we performed a large scale bicolor interphase cytogenetic (fluorescence in situ hybridization) study on 188 well-characterized B-NHLs classified according to the World Health Organization Classification of Tumors of the Lymphoid Tissues. BCL6 rearrangements were detected in a significantly higher number of FL3B with a DLBL component (12 of 22, 55%) compared with purely diffuse nodal DLBLs (19 of 77, 25%) and DLBLs with a well-documented primary extranodal origin (2 of 27, 7%) (P < 0.001). Five FL3B without a DLBL component were negative for both t(14;18) and 3q27 aberrations. FL grades 1/2 and FL3A were t(14;18)-positive in 88% and 64% of cases, respectively, but 3q27 alterations were identified in only four FL3A. These data exemplify different genetic pathways in the genesis of FLs with a high content of centroblasts and suggest that 3q27 rearrangements are predominantly associated with FL grade 3B harboring a DLBL component.
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