ArticleThe American journal of pathology2004
Degranulation of paneth cells via toll-like receptor 9.
Article in The American journal of pathology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 159 citations in OpenAlex.
- The gut-heart axis: a correlation between Paneth cells' dysfunction, microbiome dysbiosis, and cardiovascular diseases.Cell communication and signaling : CCS · 2025Review
- Harnessing autophagy: A potential breakthrough in digestive disease treatment.World journal of gastroenterology · 2024Article
- Infection and inflammation stimulate expansion of a CD74The EMBO journal · 2023Article
- Paneth cells in farm animals: current status and future direction.Journal of animal science and biotechnology · 2023Review
- Paneth cell dysfunction in radiation injury and radio-mitigation by human α-defensin 5.Frontiers in immunology · 2023Article
- Intestinal serotonergic system is modulated by Toll-like receptor 9.Journal of physiology and biochemistry · 2022Article
- Orally administered Lactobacillus casei exhibited several probiotic properties in artificially suckling rabbits.Asian-Australasian journal of animal sciences · 2020Article
- An Update Review on the Paneth Cell as Key to Ileal Crohn's Disease.Frontiers in immunology · 2020Review
- Immunity, microbiota and kidney disease.Nature reviews. Nephrology · 2019Review
- TLR4 Agonist Monophosphoryl Lipid A Alleviated Radiation-Induced Intestinal Injury.Journal of immunology research · 2019Article
- From Entry to Early Dissemination-Frontiers in cellular and infection microbiology · 2019Review
- Two-photon microscopy of Paneth cells in the small intestine of live mice.Scientific reports · 2018Article
- Expression profiling of Tas2r genes reveals a complex pattern along the mouse GI tract and the presence of Tas2r131 in a subset of intestinal Paneth cells.Cellular and molecular life sciences : CMLS · 2018Article
- Composition and immuno-stimulatory properties of extracellular DNA from mouse gut flora.World journal of gastroenterology · 2017Article
- Gut Microbial Influences on the Mammalian Intestinal Stem Cell Niche.Stem cells international · 2017Review
- Compartmentalizing intestinal epithelial cell toll-like receptors for immune surveillance.Cellular and molecular life sciences : CMLS · 2015Review
- Pattern recognition receptors in the gut: analysis of their expression along the intestinal tract and the crypt/villus axis.Physiological reports · 2015Article
- Interactions between Innate Immunity, Microbiota, and Probiotics.Journal of immunology research · 2015Review
- Interplay between Candida albicans and the antimicrobial peptide armory.Eukaryotic cell · 2014Review
- Interleukin-13-mediated paneth cell degranulation and antimicrobial peptide release.Journal of innate immunity · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The release of antimicrobial peptides and growth factors by Paneth cells is thought to play an important role in protecting the small intestine, but the mechanisms involved have remained obscure. Immunohistochemistry and immunofluorescence showed that Paneth cells express Toll-like receptor 9 (TLR9) in the granules. Injection of mice with oligonucleotides containing CpG sequence (CpG-ODNs) led to a down-modulation of TLR9 and a striking decrease in the number of large secretory granules, consistent with degranulation. Moreover CpG-ODN treatment increased resistance to oral challenge with virulent Salmonella typhimurium. Moreover, our findings demonstrate a sentinel role for Paneth cells through TLR9.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.