ReviewPaediatric respiratory reviews2004
Mechanisms of rhinovirus-induced asthma.
Review in Paediatric respiratory reviews, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 78 citations in OpenAlex.
- Immunopathogenesis and Cytokine Pathways in Reactive Infectious Mucocutaneous Eruption (RIME) in Pediatric Population: Infectious Triggers and Molecular Insights.Clinical reviews in allergy & immunology · 2026Review
- Respiratory viral co-detection in paediatric SARS-CoV-2 infection: associations with viral co-circulation and clinical phenotypes.Memorias do Instituto Oswaldo Cruz · 2026Article
- Common cold.Frontiers in allergy · 2023Review
- Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication.Nature communications · 2022Article
- Potentiation of long-acting βRespiratory research · 2021Article
- Asthma and COVID-19: Emphasis on Adequate Asthma Control.Canadian respiratory journal · 2021Review
- Respiratory Syncytial Virus and Rhinovirus Bronchiolitis Are Associated With Distinct Metabolic Pathways.The Journal of infectious diseases · 2018Article
- The impact of respiratory viruses on lung health after preterm birth.European clinical respiratory journal · 2018Review
- Hospitalizations and outpatient visits for rhinovirus-associated acute respiratory illness in adults.The Journal of allergy and clinical immunology · 2016Article
- Understanding the Association of Human Rhinovirus with Asthma.Clinical and vaccine immunology : CVI · 2016Review
- Macrolides: from in vitro anti-inflammatory and immunomodulatory properties to clinical practice in respiratory diseases.European journal of clinical pharmacology · 2012Review
- The role of allergy in severe asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2012Review
- Host and viral factors associated with severity of human rhinovirus-associated infant respiratory tract illness.The Journal of allergy and clinical immunology · 2011Article
- Interleukin-13-induced mucous metaplasia increases susceptibility of human airway epithelium to rhinovirus infection.American journal of respiratory cell and molecular biology · 2010Article
- New human rhinovirus species and their significance in asthma exacerbation and airway remodeling.Immunology and allergy clinics of North America · 2010Review
- Role of adenoidectomy in otitis media and respiratory function.Current allergy and asthma reports · 2010Review
- High prevalence of human rhinovirus C infection in Thai children with acute lower respiratory tract disease.The Journal of infection · 2009Article
- A novel group of rhinoviruses is associated with asthma hospitalizations.The Journal of allergy and clinical immunology · 2009Article
- Detection of respiratory viruses by molecular methods.Clinical microbiology reviews · 2008Review
- The epithelial anion transporter pendrin is induced by allergy and rhinovirus infection, regulates airway surface liquid, and increases airway reactivity and inflammation in an asthma model.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several epidemiological studies using sensitive detection methodologies have confirmed that the majority of acute asthma exacerbations follow upper respiratory tract infections--common colds. Most of these colds are due to human rhinoviruses (RVs). RVs are able to reach and replicate in epithelial cells of the lower airways and can activate these cells to produce pro-inflammatory mediators. Under some circumstances, RVs can also become cytotoxic to the epithelium. Atopic asthmatic individuals produce less interferon-gamma and more interleukin-10 than normal subjects in response to RV infection. Symptom severity as well as viral shedding after experimental RV infection, is inversely correlated with 'atopic' status, expressed as the interferon-gamma to interleukin-5 ratio. Expression of co-stimulatory molecules on immune cells is also affected in atopic asthmatics, suggesting an aberrant immune response to RV that may lead to suboptimal viral clearance and viral persistence. Some of the above effects can be reversed in vitro by corticosteroids, second-generation antihistamines or anti-oxidants; however, the optimal strategy for treating acute asthma exacerbations requires further research at both mechanistic and clinical levels.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.