ArticleThe Plant cell2004
The Ustilago maydis a2 mating-type locus genes lga2 and rga2 compromise pathogenicity in the absence of the mitochondrial p32 family protein Mrb1.
Article in The Plant cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 53 citations in OpenAlex.
- Comparative mitogenomic analysis ofFrontiers in physiology · 2024Article
- Systematic characterization ofFrontiers in microbiology · 2023Article
- Recombination suppression and evolutionary strata around mating-type loci in fungi: documenting patterns and understanding evolutionary and mechanistic causes.The New phytologist · 2021Review
- The Pheromone and Pheromone Receptor Mating-Type Locus Is Involved in Controlling Uniparental Mitochondrial Inheritance inGenetics · 2020Article
- Non-AUG Translation Initiation Generates Peroxisomal Isoforms of 6-Phosphogluconate Dehydrogenase in Fungi.Frontiers in cell and developmental biology · 2020Article
- Multi-functional, multicompartmental hyaluronan-binding protein 1 (HABP1/p32/gC1qR): implication in cancer progression and metastasis.Oncotarget · 2018Review
- Comparative whole-genome analysis reveals artificial selection effects on Ustilago esculenta genome.DNA research : an international journal for rapid publication of reports on genes and genomes · 2017Article
- Comparative Analysis Highlights Variable Genome Content of Wheat Rusts and Divergence of the Mating Loci.G3 (Bethesda, Md.) · 2017Article
- Peroxisomes, lipid droplets, and endoplasmic reticulum "hitchhike" on motile early endosomes.The Journal of cell biology · 2015Article
- Uniparental mitochondrial DNA inheritance is not affected in Ustilago maydis Δatg11 mutants blocked in mitophagy.BMC microbiology · 2015Article
- The mitochondrial Dnm1-like fission component is required for lgA2-induced mitophagy but dispensable for starvation-induced mitophagy in Ustilago maydis.Eukaryotic cell · 2012Article
- The mitochondrial LSU rRNA group II intron of Ustilago maydis encodes an active homing endonuclease likely involved in intron mobility.PloS one · 2012Article
- Interspecific sex in grass smuts and the genetic diversity of their pheromone-receptor system.PLoS genetics · 2011Article
- Hydrogen peroxide acts on sensitive mitochondrial proteins to induce death of a fungal pathogen revealed by proteomic analysis.PloS one · 2011Article
- The evolution of sex: a perspective from the fungal kingdom.Microbiology and molecular biology reviews : MMBR · 2010Review
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- An Ustilago maydis gene involved in H2O2 detoxification is required for virulence.The Plant cell · 2007Article
- The Clp1 protein is required for clamp formation and pathogenic development of Ustilago maydis.The Plant cell · 2006Article
- Mating type loci of Sporisorium reilianum: novel pattern with three a and multiple b specificities.Eukaryotic cell · 2005Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Ustilago maydis mrb1 gene specifies a mitochondrial matrix protein with significant similarity to mitochondrial p32 family proteins known from human and many other eukaryotic species. Compatible mrb1 mutant strains were able to mate and form dikaryotic hyphae; however, proliferation within infected tissue and the ability to induce tumor development of infected maize (Zea mays) plants were drastically impaired. Surprisingly, manifestation of the mrb1 mutant phenotype selectively depended on the a2 mating type locus. The a2 locus contains, in addition to pheromone signaling components, the genes lga2 and rga2 of unknown function. Deletion of lga2 in an a2Deltamrb1 strain fully restored pathogenicity, whereas pathogenicity was partially regained in an a2Deltamrb1Deltarga2 strain, implicating a concerted action between Lga2 and Rga2 in compromising pathogenicity in Deltamrb1 strains. Lga2 and Rga2 localized to mitochondria and Mrb1 interacted with Rga2 in the yeast two-hybrid system. Conditional expression of lga2 in haploid cells reduced vegetative growth, conferred mitochondrial fragmentation and mitochondrial DNA degradation, and interfered with respiratory activity. The consequences of lga2 overexpression depended on the expression strength and were greatly exacerbated in Deltamrb1 mutants. We propose that Lga2 interferes with mitochondrial fusion and that Mrb1 controls this activity, emphasizing a critical link between mitochondrial morphology and pathogenicity.
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