Trial reportAntimicrobial agents and chemotherapy2004
Relationship between triclosan and susceptibilities of bacteria isolated from hands in the community.
Trial report in Antimicrobial agents and chemotherapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 83 citations in OpenAlex.
- Antibacterial cleaning products and drug resistance.Emerging infectious diseases · 2005Trial
- Disinfectant-induced bacterial resistance and antibiotic cross-resistance-mechanisms and clinical relevance.Clinical and experimental medicine · 2025Review
- Resistance and Biodegradation of Triclosan and Propylparaben by Isolated Bacteria from Greywater.Journal of xenobiotics · 2025Article
- Do Triclosan Sutures Modify the Microbial Diversity of Surgical Site Infections? A Systematic Review and Meta-Analysis.Microorganisms · 2022Review
- Assessing the risk of resistance to cationic biocides incorporating realism-based and biophysical approaches.Journal of industrial microbiology & biotechnology · 2022Review
- Antimicrobial Resistance Following Prolonged Use of Hand Hygiene Products: A Systematic Review.Pharmacy (Basel, Switzerland) · 2022Review
- Triclosan Tolerance Is Driven by a Conserved Mechanism in DiverseApplied and environmental microbiology · 2021Article
- Contribution of Time, Taxonomy, and Selective Antimicrobials to Antibiotic and Multidrug Resistance in Wastewater Bacteria.Environmental science & technology · 2020Article
- Loss of Function in Escherichia coli Exposed to Environmentally Relevant Concentrations of Benzalkonium Chloride.Applied and environmental microbiology · 2019Article
- Resistance of Bacteria to Biocides.Microbiology spectrum · 2018Review
- The Florence Statement on Triclosan and Triclocarban.Environmental health perspectives · 2017Article
- Triclosan: A Widespread Environmental Toxicant with Many Biological Effects.Annual review of pharmacology and toxicology · 2016Review
- Development of a protocol for predicting bacterial resistance to microbicides.Applied and environmental microbiology · 2015Article
- On the need and speed of regulating triclosan and triclocarban in the United States.Environmental science & technology · 2014Article
- Staphylococcus epidermidis isolated in 1965 are more susceptible to triclosan than current isolates.PloS one · 2013Article
- The frequency of antibiotic-resistant bacteria in homes differing in their use of surface antibacterial agents.Current microbiology · 2012Article
- Occurrence and toxicity of antimicrobial triclosan and by-products in the environment.Environmental science and pollution research international · 2012Review
- Triclosan antagonizes fluconazole activity against Candida albicans.Journal of dental research · 2012Article
- Antimicrobial sutures and prevention of surgical site infection: assessment of the safety of the antiseptic triclosan.International wound journal · 2011Review
- Healthcare associated infection: novel strategies and antimicrobial implants to prevent surgical site infection.Annals of the Royal College of Surgeons of England · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
The possible association between triclosan and bacterial susceptibility to antibiotic was examined among staphylococci and several species of gram-negative bacteria (GNB) isolated from the hands of individuals in a community setting. Hand cultures from individuals randomized to using either antibacterial cleaning and hygiene products (including a hand soap containing 0.2% triclosan) or nonantibacterial cleaning and hygiene products for a 1-year period were taken at baseline and at the end of the year. Although there was no statistically significant association between triclosan MICs and susceptibility to antibiotic, there was an increasing trend in the association the odds ratios (ORs) for all species were compared at baseline (OR = 0.65, 95% confidence interval [95%CI] = 0.33 to 1.27) versus at the end of the year (OR = 1.08, 95%CI = 0.62 to 1.97) and for GNB alone at baseline(OR = 0.66, 95%CI = 0.29 to 1.51) versus the end of year (OR = 2.69, 95%CI = 0.78 to 9.23) regardless of the hand-washing product used. Moreover, triclosan MICs were higher in some of the species compared to earlier reports on household, clinical, and industrial isolates, and some of these isolates had triclosan MICs in the range of concentrations used in consumer products. The absence of a statistically significant association between elevated triclosan MICs and reduced antibiotic susceptibility may indicate that such a correlation does not exist or that it is relatively small among the isolates that were studied. Still, a relationship may emerge after longer-term or higher-dose exposure of bacteria to triclosan in the community setting.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.