ArticleThe Journal of physiology2004
Neurotransmitter modulation of extracellular H+ fluxes from isolated retinal horizontal cells of the skate.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- ATP-mediated increase in HJournal of neurophysiology · 2024Article
- Review and Hypothesis: A Potential Common Link Between Glial Cells, Calcium Changes, Modulation of Synaptic Transmission, Spreading Depression, Migraine, and Epilepsy-HFrontiers in cellular neuroscience · 2021Article
- Extracellular ATP-Induced Alterations in Extracellular HFrontiers in cellular neuroscience · 2021Article
- Activation of retinal glial (Müller) cells by extracellular ATP induces pronounced increases in extracellular H+ flux.PloS one · 2018Article
- Membrane-associated guanylate kinase scaffolds organize a horizontal cell synaptic complex restricted to invaginating contacts with photoreceptors.The Journal of comparative neurology · 2017Article
- Calcium dynamics and regulation in horizontal cells of the vertebrate retina: lessons from teleosts.Journal of neurophysiology · 2017Review
- Measurement of extracellular ion fluxes using the ion-selective self-referencing microelectrode technique.Journal of visualized experiments : JoVE · 2015Article
- Fluorescent imaging reports an extracellular alkalinization induced by glutamatergic activation of isolated retinal horizontal cells.Journal of neurophysiology · 2014Article
- Engaging Undergraduates in a Unique Neuroscience Research Opportunity: A Collaborative Research Experience Between a Primarily Undergraduate Institution (PUI) and a Major Research Institution.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2013Article
- Distinctive patterns of alterations in proton efflux from goldfish retinal horizontal cells monitored with self-referencing H⁺-selective electrodes.The European journal of neuroscience · 2012Article
- Lateral interactions in the outer retina.Progress in retinal and eye research · 2012Review
- Acidification of the synaptic cleft of cone photoreceptor terminal controls the amount of transmitter release, thereby forming the receptive field surround in the vertebrate retina.The journal of physiological sciences : JPS · 2012Review
- Extracellular pH dynamics of retinal horizontal cells examined using electrochemical and fluorometric methods.Journal of neurophysiology · 2012Article
- Ion-selective self-referencing probes for measuring specific ion flux.Communicative & integrative biology · 2011Article
- Barium plateau potentials of CA1 pyramidal neurons elicit all-or-none extracellular alkaline shifts via the plasma membrane calcium ATPase.Journal of neurophysiology · 2010Article
- Rapid rise of extracellular pH evoked by neural activity is generated by the plasma membrane calcium ATPase.Journal of neurophysiology · 2010Article
- Depolarization of isolated horizontal cells of fish acidifies their immediate surrounding by activating V-ATPase.The Journal of physiology · 2007Article
- Modulation of extracellular proton fluxes from retinal horizontal cells of the catfish by depolarization and glutamate.The Journal of general physiology · 2007Article
- Proton-mediated feedback inhibition of presynaptic calcium channels at the cone photoreceptor synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Self-referencing H(+)-selective microelectrodes were used to measure extracellular H(+) fluxes from horizontal cells isolated from the skate retina. A standing H(+) flux was detected from quiescent cells, indicating a higher concentration of free hydrogen ions near the extracellular surface of the cell as compared to the surrounding solution. The standing H(+) flux was reduced by removal of extracellular sodium or application of 5-(N-ethyl-N-isopropyl) amiloride (EIPA), suggesting activity of a Na(+)-H(+) exchanger. Glutamate decreased H(+) flux, lowering the concentration of free hydrogen ions around the cell. AMPA/kainate receptor agonists mimicked the response, and the AMPA/kainate receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) eliminated the effects of glutamate and kainate. Metabotropic glutamate agonists were without effect. Glutamate-induced alterations in H(+) flux required extracellular calcium, and were abolished when cells were bathed in an alkaline Ringer solution. Increasing intracellular calcium by photolysis of the caged calcium compound NP-EGTA also altered extracellular H(+) flux. Immunocytochemical localization of the plasmalemma Ca(2+)-H(+)-ATPase (PMCA pump) revealed intense labelling within the outer plexiform layer and on isolated horizontal cells. Our results suggest that glutamate modulation of H(+) flux arises from calcium entry into cells with subsequent activation of the plasmalemma Ca(2+)-H(+)-ATPase. These neurotransmitter-induced changes in extracellular pH have the potential to play a modulatory role in synaptic processing in the outer retina. However, our findings argue against the hypothesis that hydrogen ions released by horizontal cells normally act as the inhibitory feedback neurotransmitter onto photoreceptor synaptic terminals to create the surround portion of the centre-surround receptive fields of retinal neurones.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.