ArticleThe Journal of physiology2004
An estimate of the resting membrane resistance of frog olfactory receptor neurones.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- A Comparison of the Primary Sensory Neurons Used in Olfaction and Vision.Frontiers in cellular neuroscience · 2020Review
- Impact of mTOR hyperactive neurons on the morphology and physiology of adjacent neurons: Do PTEN KO cells make bad neighbors?Experimental neurology · 2019Article
- PTEN deletion increases hippocampal granule cell excitability in male and female mice.Neurobiology of disease · 2017Article
- Properties of an optogenetic model for olfactory stimulation.The Journal of physiology · 2016Article
- Signaling by olfactory receptor neurons near threshold.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Integration of K+ and Cl- currents regulate steady-state and dynamic membrane potentials in cultured rat microglia.The Journal of physiology · 2005Article
- Ionic conductances in sustentacular cells of the mouse olfactory epithelium.The Journal of physiology · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The ability of a frog olfactory receptor neurone (ORN) to respond to odorous molecules depends on its resting membrane properties, including membrane resistance and potential. Quantification of these properties is difficult because of a shunt conductance at the membrane-pipette seal that is in parallel with the true membrane conductance. In physiological salines, the sum of these two conductances averaged 235 pS. We used ionic substitution and channel blockers to reduce the membrane conductance as much as possible. This yielded a lower limit for the membrane conductance of 158 pS. The upper limit of resting membrane resistance, then, is 6 GOmega. The membrane is permeable to K+ and, to a lesser extent, other cations. No resting Cl- conductance was detectable. Correcting measured zero-current potentials for distortion by the shunt suggests that the resting membrane potential is no more negative than -75 mV. The present results help to explain why frog ORNs are excitable at rest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.