ArticleThe Journal of physiology2004
Principal neuron spiking: neither necessary nor sufficient for cerebral blood flow in rat cerebellum.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- A 7T fMRI study of cerebellar activation in sequential finger movement tasks.Experimental brain research · 2013Trial
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- Functional recruitment and connectivity of the cerebellum is associated with the emergence of Theory of Mind in early childhood.Nature communications · 2025Article
- Maternal immune activation followed by peripubertal stress combinedly produce reactive microglia and confine cerebellar cognition.Communications biology · 2025Article
- Cerebello-Cerebral Pathways Contribute to Written Word Production.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Transcriptomic gradients of the human cerebellum.Imaging neuroscience (Cambridge, Mass.) · 2025Article
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- Controversies and progress on standardization of large-scale brain network nomenclature.Network neuroscience (Cambridge, Mass.) · 2023Article
- Building bridges: simultaneous multimodal neuroimaging approaches for exploring the organization of brain networks.Neurophotonics · 2022Review
- Review
- Surface color and predictability determine contextual modulation of V1 firing and gamma oscillations.eLife · 2019Article
- Electrophysiological Source Imaging: A Noninvasive Window to Brain Dynamics.Annual review of biomedical engineering · 2018Review
- Simultaneous GCaMP6-based fiber photometry and fMRI in rats.Journal of neuroscience methods · 2017Article
- Granular Layer Neurons Control Cerebellar Neurovascular Coupling Through an NMDA Receptor/NO-Dependent System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Interpreting BOLD: towards a dialogue between cognitive and cellular neuroscience.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Interneurons contribute to the hemodynamic/metabolic response to epileptiform discharges.Journal of neurophysiology · 2016Article
- Preclinical Magnetic Resonance Imaging and Spectroscopy Studies of Memory, Aging, and Cognitive Decline.Frontiers in aging neuroscience · 2016Review
- Optogenetic stimulation of GABA neurons can decrease local neuronal activity while increasing cortical blood flow.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Task-Driven Activity Reduces the Cortical Activity Space of the Brain: Experiment and Whole-Brain Modeling.PLoS computational biology · 2015Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuronal activity, cerebral blood flow, and metabolic responses are all strongly coupled, although the mechanisms behind the coupling remain unclear. One of the key questions is whether or not increases in spiking activity in the stimulated neurons are sufficient to drive the activity-dependent rises in cerebral blood flow (CBF) that form the basis of the signals used in functional neuroimaging such as the blood oxygen level-dependent (BOLD) signal. To this end the present study examined the effect of enhanced spike activity per se on CBF in rat cerebellar cortex under conditions of disinhibition, achieved by blocking GABA(A) receptors using either bicuculline or picrotoxin. Purkinje cell spiking activity and local field potentials were recorded by glass microelectrodes, and laser Doppler flowmetry was used to monitor CBF. Disinhibition increased Purkinje cell spiking rate to 200-300% of control without incurring any increase in basal CBF. This demonstrates that increased spike activity per se is not sufficient to affect basal CBF. The neurovascular coupling between excitatory synaptic activity and CBF responses evoked by inferior olive (climbing fibre) stimulation was preserved during disinhibition. Thus, the unchanged basal CBF in the presence of the dramatic rise in Purkinje cell spiking rate was not explained by impaired synaptic activity-CBF coupling. On the basis of our previous and the present studies, we conclude that increased spiking activity of principal neurons is neither sufficient nor necessary to elicit CBF responses and in turn BOLD signals, and that activation-dependent vascular signals reflect excitatory synaptic activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.