ArticleThe Journal of physiology2004
Ca(2+) and K(+) (BK) channels in chick hair cells are clustered and colocalized with apical-basal and tonotopic gradients.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Molecular Choreography and Structure of CaMembranes · 2020Review
- Calcium-induced calcium release in proximity to hair cell BK channels revealed by PKA activation.Physiological reports · 2020Article
- Distinct Evolutionary Trajectories of Neuronal and Hair Cell Nicotinic Acetylcholine Receptors.Molecular biology and evolution · 2020Article
- Anatomic and Physiologic Heterogeneity of Subgroup-A Auditory Sensory Neurons in Fruit Flies.Frontiers in neural circuits · 2017Article
- BK Channels in the Central Nervous System.International review of neurobiology · 2016Review
- Time-Dependent Effects of Ethanol on BK Channel Expression and Trafficking in Hippocampal Neurons.Alcoholism, clinical and experimental research · 2015Article
- Long-term hypoxia increases calcium affinity of BK channels in ovine fetal and adult cerebral artery smooth muscle.American journal of physiology. Heart and circulatory physiology · 2015Article
- Tracking the molecular evolution of calcium permeability in a nicotinic acetylcholine receptor.Molecular biology and evolution · 2014Article
- Plasticity in ion channel expression underlies variation in hearing during reproductive cycles.Current biology : CB · 2013Article
- Electrical tuning and transduction in short hair cells of the chicken auditory papilla.Journal of neurophysiology · 2013Article
- Functional coupling between large-conductance potassium channels and Cav3.2 voltage-dependent calcium channels participates in prostate cancer cell growth.Biology open · 2013Article
- Hair cell BK channels interact with RACK1, and PKC increases its expression on the cell surface by indirect phosphorylation.American journal of physiology. Cell physiology · 2012Article
- CDK5 interacts with Slo and affects its surface expression and kinetics through direct phosphorylation.American journal of physiology. Cell physiology · 2012Article
- Gene expression gradients along the tonotopic axis of the chicken auditory epithelium.Journal of the Association for Research in Otolaryngology : JARO · 2011Article
- Spatial organization of RYRs and BK channels underlying the activation of STOCs by Ca(2+) sparks in airway myocytes.The Journal of general physiology · 2011Article
- A search for factors specifying tonotopy implicates DNER in hair-cell development in the chick's cochlea.Developmental biology · 2011Article
- β4-subunit increases Slo responsiveness to physiological Ca2+ concentrations and together with β1 reduces surface expression of Slo in hair cells.American journal of physiology. Cell physiology · 2011Article
- Structural and functional effects of acoustic exposure in goldfish: evidence for tonotopy in the teleost saccule.BMC neuroscience · 2011Article
- Interactions between β-catenin and the HSlo potassium channel regulates HSlo surface expression.PloS one · 2011Article
- Distribution of high-conductance calcium-activated potassium channels in rat vestibular epithelia.The Journal of comparative neurology · 2009Article
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4 authors.
Funding
Abstract
Electrical resonance is a mechanism used by birds and many vertebrates to discriminate between frequencies of sound, and occurs when the intrinsic oscillation in the membrane potential of a specific hair cell corresponds to a specific stimulus sound frequency. This intrinsic oscillation results from an interplay between an inward Ca(2+) current and the resultant activation of a hyperpolarizing Ca(2+)-activated K(+) current. These channels are predicted to lie in close proximity owing to the fast oscillation in membrane potential. The interplay of these channels is widespread in the nervous system, where they perform numerous roles including the control of synaptic release, burst frequency and circadian rhythm generation. Here, we used confocal microscopy to show that these two ion channels are clustered and colocalized in the chick hair cell membrane. The majority of Ca(2+) channels were colocalized while the proportion of colocalized BK channels was markedly less. In addition, we report both an apical-basal gradient of these clusters in individual hair cells, as well as a gradient in the number of clusters between hair cells along the tonotopic axis. These results give physical confirmation of previous predictions. Since the proportion of colocalized channels was a constant function of Ca(2+) channels, and not of BK channels, these results suggest that their colocalization is determined by the former. The molecular mechanisms underpinning their clustering and colocalization are likely to be common to other neuronal cells.
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