ArticleInfection and immunity2004
Intact purine biosynthesis pathways are required for wild-type virulence of Brucella abortus 2308 in the BALB/c mouse model.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 62 citations in OpenAlex.
- A genome-wide CRISPR knockout screen identified host genes essential for Brucella invasion and intracellular survival.Emerging microbes & infections · 2026Article
- De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence.MicrobiologyOpen · 2026Review
- Genome-wide identification of metabolic and regulatory determinants of intracellular growth inbioRxiv : the preprint server for biology · 2026Article
- A requirement formSphere · 2026Article
- UnravelingmSystems · 2025Article
- Disruption of purineFrontiers in microbiology · 2025Article
- Lactate promotes the biofilm-to-invasive-planktonic transition inInfection and immunity · 2024Article
- Genome-wide analysis of Brucella melitensis growth in spleen of infected mice allows rational selection of new vaccine candidates.PLoS pathogens · 2024Article
- Pathophysiologic Insights into the Transition from Asymptomatic Bacteriuria to Urinary Tract Infection.Current urology reports · 2023Review
- Antibiogram Screening and Detection of Virulence-Associated Genes inInternational journal of environmental research and public health · 2022Article
- Identification of genetic elements required forFrontiers in microbiology · 2022Article
- Whole-genome sequencing reveals high genetic diversity of Streptococcus uberis isolated from cows with mastitis.BMC veterinary research · 2021Article
- Time-Resolved Proteome Analysis ofmSystems · 2021Article
- Interspecies Metabolic Complementation in Cystic Fibrosis Pathogens via Purine Exchange.Pathogens (Basel, Switzerland) · 2021Article
- Article
- Artificial Selection for Pathogenicity Mutations inInfection and immunity · 2019Article
- Identification of Genetic Features for Attenuation of TwoFrontiers in veterinary science · 2019Article
- Development of new generation of vaccines forHeliyon · 2018Review
- Probing the Genome-Scale Metabolic Landscape of Bordetella pertussis, the Causative Agent of Whooping Cough.Applied and environmental microbiology · 2017Article
- Development and trial of vaccines againstJournal of veterinary science · 2017Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Brucella abortus 2308 derivatives with mini-Tn5 insertions in purE, purL, and purD display significant attenuation in the BALB/c mouse model, while isogenic mutants with mini-Tn5 insertions in pheA, trpB, and dagA display little or no attenuation in cultured murine macrophages or mice. These experimental findings confirm the importance of the purine biosynthesis pathways for the survival and replication of the brucellae in host macrophages. In contrast to previous reports, however, these results indicate that exogenous tryptophan and phenylalanine are available for use by the brucellae in the phagosomal compartment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.