ArticleInfection and immunity2004
YAPI, a new Yersinia pseudotuberculosis pathogenicity island.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
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- Genomic Islands of Pseudomonas syringae pv. tabaci 6605: Identification of PtaGI-1 as a Pathogenicity Island With Effector Genes and a Tabtoxin Cluster.Molecular plant pathology · 2025Article
- Sequence analysis of tyrosine recombinases allows annotation of mobile genetic elements in prokaryotic genomes.Molecular systems biology · 2021Article
- Transcriptomic Analysis of Yersinia enterocolitica Biovar 1B Infecting Murine Macrophages Reveals New Mechanisms of Extracellular and Intracellular Survival.Infection and immunity · 2015Article
- Parallel independent evolution of pathogenicity within the genus Yersinia.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The Yersinia enterocolitica Ysa type III secretion system is expressed during infections both in vitro and in vivo.MicrobiologyOpen · 2013Article
- RNA-seq reveals the RNA binding proteins, Hfq and RsmA, play various roles in virulence, antibiotic production and genomic flux in Serratia sp. ATCC 39006.BMC genomics · 2013Article
- Tracing genomic variations in two highly virulent Yersinia enterocolitica strains with unequal ability to compete for host colonization.BMC genomics · 2012Article
- Structure, diversity, and mobility of the Salmonella pathogenicity island 7 family of integrative and conjugative elements within Enterobacteriaceae.Journal of bacteriology · 2012Article
- Units of plasticity in bacterial genomes: new insight from the comparative genomics of two bacteria interacting with invertebrates, Photorhabdus and Xenorhabdus.BMC genomics · 2010Article
- The Pseudomonas aeruginosa pathogenicity island PAPI-1 is transferred via a novel type IV pilus.Journal of bacteriology · 2010Article
- Transcriptional activation of the tad type IVb pilus operon by PypB in Yersinia enterocolitica.Journal of bacteriology · 2010Article
- Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species.PloS one · 2010Article
- The pheV phenylalanine tRNA gene Klebsiella pneumoniae clinical isolates is an integration hotspot for possible niche-adaptation genomic islands.Current microbiology · 2010Article
- Genomic characterization of the Yersinia genus.Genome biology · 2010Article
- Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens.Genome biology · 2009Article
- Oral vaccination against bubonic plague using a live avirulent Yersinia pseudotuberculosis strain.Infection and immunity · 2008Article
- Overproduction of DNA adenine methyltransferase alters motility, invasion, and the lipopolysaccharide O-antigen composition of Yersinia enterocolitica.Infection and immunity · 2007Article
- The complete genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East scarlet-like fever.PLoS genetics · 2007Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathogenicity islands (PAIs) are chromosomal clusters of pathogen-specific virulence genes often found at tRNA loci. In the Yersinia pseudotuberculosis 32777 chromosome, we characterized a 98-kb segment that has all of the characteristic features of a PAI, including insertion in a (phenylalanine) tRNA gene, the presence of a bacteriophage-like integrase-encoding gene, and direct repeats at the integration sites. The G+C content of the segment ranges from 31 to 60%, reflecting a genetic mosaic: this is consistent with the notion that the sequences were horizontally acquired. The PAI, termed YAPI (for Yersinia adhesion pathogenicity island), carries 95 open reading frames and includes (i) the previously described pil operon, encoding a type IV pilus that contributes to pathogenicity (F. Collyn et al., Infect. Immun. 70:6196-6205, 2002); (ii) a block of genes potentially involved in general metabolism; (iii) a gene cluster for a restriction-modification system; and (iv) a large number of mobile genetic elements. Furthermore, the PAI can excise itself from the chromosome at low frequency and in a precise manner, and deletion does not result in a significant decrease of bacterial virulence compared to inactivation of the fimbrial gene cluster alone. The prevalence and size of the PAI vary from one Y. pseudotuberculosis strain to another, and it can be found integrated into either of the two phe tRNA loci present on the species' chromosome. YAPI was not detected in the genome of the genetically closely related species Y. pestis, whereas a homologous PAI is harbored by the Y. enterocolitica chromosome.
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