ArticleInfection and immunity2004
A STAT4-dependent Th1 response is required for resistance to the helminth parasite Taenia crassiceps.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- STAT1-Dependent Recruitment of Ly6CPathogens (Basel, Switzerland) · 2021Article
- STAT4 is expressed in neutrophils and promotes antimicrobial immunity.JCI insight · 2021Article
- Co-infection: the outcome of Plasmodium infection differs according to the time of pre-existing helminth infection.Parasitology research · 2018Article
- Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory Mouse.Journal of immunology research · 2018Review
- STAT4 is required for the generation of Th1 and Th2, but not Th17 immune responses during monophosphoryl lipid A adjuvant activity.International immunology · 2016Article
- E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo.Scientific reports · 2015Article
- EmTIP, a T-Cell immunomodulatory protein secreted by the tapeworm Echinococcus multilocularis is important for early metacestode development.PLoS neglected tropical diseases · 2014Article
- In vivo albendazole treatment of Taenia crassiceps cysticerci strain WFU: proliferation, damage, and recovery.Parasitology research · 2013Article
- Immunoregulation by Taenia crassiceps and its antigens.BioMed research international · 2013Article
- Identification of loci controlling restriction of parasite growth in experimental Taenia crassiceps cysticercosis.PLoS neglected tropical diseases · 2011Article
- Diversity and dialogue in immunity to helminths.Nature reviews. Immunology · 2011Review
- Cestode antigens induce a tolerogenic-like phenotype and inhibit LPS inflammatory responses in human dendritic cells.International journal of biological sciences · 2011Article
- Signal Transducers and Activators of Transcription (STAT) family members in helminth infections.International journal of biological sciences · 2011Review
- TLR2 mediates immunity to experimental cysticercosis.International journal of biological sciences · 2011Article
- Similarity and diversity in macrophage activation by nematodes, trematodes, and cestodes.Journal of biomedicine & biotechnology · 2010Review
- MIF homologues from a filarial nematode parasite synergize with IL-4 to induce alternative activation of host macrophages.Journal of leukocyte biology · 2009Article
- Nitric oxide contributes to host resistance against experimental Taenia crassiceps cysticercosis.Parasitology research · 2007Article
- Differential immune profiles following experimental Echinostoma hortense infection in BALB/c and C3H/HeN mice.Parasitology research · 2007Article
- Carbohydrate components of Taenia crassiceps metacestodes display Th2-adjuvant and anti-inflammatory properties when co-injected with bystander antigen.Parasitology research · 2006Article
- STAT4: a critical regulator of inflammation in vivo.Immunologic research · 2005Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To determine the role of STAT4-dependent Th1 responses in the regulation of immunity to the helminth parasite Taenia crassiceps, we monitored infections with this parasite in resistant mice lacking the STAT4 gene. While T. crassiceps-infected STAT4(+/+) mice rapidly resolved the infection, STAT4(-/-) mice were highly susceptible to infection and displayed large parasite loads. Moreover, the inability of STAT4(-/-) mice to control the infection was associated with the induction of an antigen-specific Th2-type response characterized by significantly higher levels of Th2-associated immunoglobulin G1 (IgG1) and total IgE as well as interleukin-4 (IL-4), IL-10, and IL-13 than those in STAT4(+/+) mice, who produced significantly more gamma interferon. Furthermore, early after infection, macrophages from STAT4(-/-) mice produced lower levels of the pro-inflammatory cytokines IL-12, tumor necrosis factor alpha, IL-1 beta, and nitric oxide (NO) than those from STAT4(+/+) mice, suggesting a pivotal role for macrophages in mediating protection against cysticercosis. These findings demonstrate a critical role for the STAT4 signaling pathway in the development of a Th1-type immune response that is essential for mediating protection against the larval stage of T. crassiceps infection.
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