ArticleInfection and immunity2004
A specific genomic location within the icm/dot pathogenesis region of different Legionella species encodes functionally similar but nonhomologous virulence proteins.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Legionellosis Caused by Non-Microorganisms · 2021Review
- Genomic analysis of 38 Legionella species identifies large and diverse effector repertoires.Nature genetics · 2016Article
- Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires' disease.Genome biology · 2014Article
- IcmQ in the Type 4b secretion system contains an NAD+ binding domain.Structure (London, England : 1993) · 2013Article
- Type IVB Secretion Systems of Legionella and Other Gram-Negative Bacteria.Frontiers in microbiology · 2011Article
- Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions.Frontiers in microbiology · 2011Article
- Analysis of the Legionella longbeachae genome and transcriptome uncovers unique strategies to cause Legionnaires' disease.PLoS genetics · 2010Article
- Virulence factors encoded by Legionella longbeachae identified on the basis of the genome sequence analysis of clinical isolate D-4968.Journal of bacteriology · 2010Article
- Exploitation of Host Polyubiquitination Machinery through Molecular Mimicry by Eukaryotic-Like Bacterial F-Box Effectors.Frontiers in microbiology · 2010Article
- Structure and function of interacting IcmR-IcmQ domains from a type IVb secretion system in Legionella pneumophila.Structure (London, England : 1993) · 2009Article
- Identification of a hypervariable region containing new Legionella pneumophila Icm/Dot translocated substrates by using the conserved icmQ regulatory signature.Infection and immunity · 2008Article
- CpxRA regulates mutualism and pathogenesis in Xenorhabdus nematophila.Applied and environmental microbiology · 2007Article
- A pair of highly conserved two-component systems participates in the regulation of the hypervariable FIR proteins in different Legionella species.Journal of bacteriology · 2007Article
- Identification of Legionella pneumophila-specific genes by genomic subtractive hybridization with Legionella micdadei and identification of lpnE, a gene required for efficient host cell entry.Infection and immunity · 2006Article
- Coevolution between nonhomologous but functionally similar proteins and their conserved partners in the Legionella pathogenesis system.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Biological Diversity and Evolution of Type IV Secretion Systems.Current topics in microbiology and immunologyArticle
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2 authors.
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Abstract
Legionella pneumophila, the major causative agent of Legionnaires' disease, is a facultative intracellular pathogen that grows within human macrophages and amoebae. Intracellular growth involves the formation of a replicative phagosome that requires the Icm/Dot type IV secretion system. Part of the icm/dot region in L. pneumophila contains the icmTSRQPO genes. The proteins encoded by the icmR and icmQ genes were shown to exhibit a chaperone-substrate relationship. Analysis of this region from other pathogenic Legionella species, i.e., L. micdadei and L. longbeachae, indicated that the overall organization of this region is highly conserved, but it was found to contain a favorable site for gene variation. In the place where the icmR gene was expected to be located, other open reading frames that are nonhomologous to each other or to any entry in the GenBank database were found (migAB in L. micdadei and ligB in L. longbeachae). Examination of these unique genes revealed an outstanding phenomenon; by use of interspecies complementation, the icmR, migB, and ligB gene products were found to be functionally similar. In addition, the function of these proteins was usually dependent on the presence of the corresponding IcmQ proteins. Moreover, each of these proteins (IcmR, LigB, and MigB) was found to interact with the corresponding IcmQ proteins, and the genes encoding these proteins were found to be regulated by CpxR. This study reveals new evidence of gene variation occurring in the same genomic location within the icm/dot locus in various Legionella species. The genes found at this site were shown to be similarly regulated and to encode species-specific, nonhomologous, but functionally similar proteins.
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