ArticleInfection and immunity2004
The major subunit of the toxin-coregulated pilus TcpA induces mucosal and systemic immunoglobulin A immune responses in patients with cholera caused by Vibrio cholerae O1 and O139.
Article in Infection and immunity, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- The Live Attenuated Cholera Vaccine CVD 103-HgR Primes Responses to the Toxin-Coregulated Pilus Antigen TcpA in Subjects Challenged with Wild-Type Vibrio cholerae.Clinical and vaccine immunology : CVI · 2017Trial
- InactivatedJournal of microbiology and biotechnology · 2022Article
- Transmission of SARS-CoV-2 in the Population Living in High- and Low-Density Gradient Areas in Dhaka, Bangladesh.Tropical medicine and infectious disease · 2022Article
- IgM specific to lipopolysaccharide of Vibrio cholerae is a surrogate antibody isotype responsible for serum vibriocidal activity.PloS one · 2019Article
- Plasma and Mucosal Immunoglobulin M, Immunoglobulin A, and Immunoglobulin G Responses to the Vibrio cholerae O1 Protein Immunome in Adults With Cholera in Bangladesh.The Journal of infectious diseases · 2017Article
- Production of putative enhanced oral cholera vaccine strains that express toxin-coregulated pilus.PloS one · 2017Article
- Cholera in pregnancy: Clinical and immunological aspects.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2015Observational
- Critical analysis of compositions and protective efficacies of oral killed cholera vaccines.Clinical and vaccine immunology : CVI · 2014Review
- Lipopolysaccharide modifications of a cholera vaccine candidate based on outer membrane vesicles reduce endotoxicity and reveal the major protective antigen.Infection and immunity · 2013Article
- Study of avidity of antigen-specific antibody as a means of understanding development of long-term immunological memory after Vibrio cholerae O1 infection.Clinical and vaccine immunology : CVI · 2013Article
- Immunology of gut mucosal vaccines.Immunological reviews · 2011Review
- Vibrio cholerae: lessons for mucosal vaccine design.Expert review of vaccines · 2011Review
- Comparison of clinical features and immunological parameters of patients with dehydrating diarrhoea infected with Inaba or Ogawa serotypes of Vibrio cholerae O1.Scandinavian journal of infectious diseases · 2010Article
- Salmonella enterica serovar Typhi-specific immunoglobulin A antibody responses in plasma and antibody in lymphocyte supernatant specimens in Bangladeshi patients with suspected typhoid fever.Clinical and vaccine immunology : CVI · 2009Article
- Memory T-cell responses to Vibrio cholerae O1 infection.Infection and immunity · 2009Article
- Antigen-specific memory B-cell responses to Vibrio cholerae O1 infection in Bangladesh.Infection and immunity · 2009Article
- Cholera caused by Vibrio cholerae O1 induces T-cell responses in the circulation.Infection and immunity · 2009Article
- A comparison of clinical and immunologic features in children and older patients hospitalized with severe cholera in Bangladesh.The Pediatric infectious disease journal · 2008Article
- Immunization with Vibrio cholerae outer membrane vesicles induces protective immunity in mice.Infection and immunity · 2008Article
- Susceptibility to Vibrio cholerae infection in a cohort of household contacts of patients with cholera in Bangladesh.PLoS neglected tropical diseases · 2008Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Diarrhea caused by Vibrio cholerae is known to give long-lasting protection against subsequent life-threatening illness. The serum vibriocidal antibody response has been well studied and has been shown to correlate with protection. However, this systemic antibody response may be a surrogate marker for mucosal immune responses to key colonization factors of this organism, such as the toxin-coregulated pilus (TCP) and other factors. Information regarding immune responses to TCP, particularly mucosal immune responses, is lacking, particularly for patients infected with the El Tor biotype of V. cholerae O1 or V. cholerae O139 since highly purified TcpA from these strains has not been available previously for use in immune assays. We studied the immune responses to El Tor TcpA in cholera patients in Bangladesh. Patients had substantial and significant increases in TcpA-specific antibody-secreting cells in the circulation on day 7 after the onset of illness, as well as similar mucosal responses as determined by an alternate technique, the assay for antibody in lymphocyte supernatant. Significant increases in antibodies to TcpA were also seen in sera and feces of patients on days 7 and 21 after the onset of infection. Overall, 93% of the patients showed a TcpA-specific response in at least one of the specimens compared with the results obtained on day 2 and with healthy controls. These results demonstrate that TcpA is immunogenic following natural V. cholerae infection and suggest that immune responses to this antigen should be evaluated for potential protection against subsequent life-threatening illness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.