ArticleClinical and experimental immunology2004
Th1 and Th2 cytokine production is suppressed at the level of transcriptional regulation in Kawasaki disease.
Article in Clinical and experimental immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Overview of T-cell subsets and related cytokines in Kawasaki disease.Pediatric research · 2026Review
- Integration of scRNA-Seq and bulk RNA-Seq uncover perturbed immune cell types and pathways of Kawasaki disease.Frontiers in immunology · 2023Article
- Intravenous Immunoglobulin Therapy Restores the Quantity and Phenotype of Circulating Dendritic Cells and CD4Frontiers in immunology · 2022Article
- The Impact of Moderate-Dose Acetylsalicylic Acid in the Reduction of Inflammatory Cytokine and Prevention of Complication in Acute Phase of Kawasaki Disease: The Benefit of Moderate-Dose Acetylsalicylic Acid.Children (Basel, Switzerland) · 2020Article
- Acute hepatitis B virus infection model within the host incorporating immune cells and cytokine responses.Theory in biosciences = Theorie in den Biowissenschaften · 2020Article
- Article
- MiR-182-5p enhances in vitro neutrophil infiltration in Kawasaki disease.Molecular genetics & genomic medicine · 2019Article
- A low-frequency IL4R locus variant in Japanese patients with intravenous immunoglobulin therapy-unresponsive Kawasaki disease.Pediatric rheumatology online journal · 2019Article
- Downregulation of Transcription Factor T-Bet as a Protective Strategy in Monosodium Urate-Induced Gouty Inflammation.Frontiers in immunology · 2019Article
- Biomarkers for Kawasaki Disease: Clinical Utility and the Challenges Ahead.Frontiers in pediatrics · 2019Review
- Variation in IL-21-secreting circulating follicular helper T cells in Kawasaki disease.BMC immunology · 2018Article
- Article
- Regulatory T cells in cardiovascular diseases.Nature reviews. Cardiology · 2016Review
- T-Helper Cytokine Profiles in Patients with Kawasaki Disease.Korean circulation journal · 2015Article
- Article
- Understanding the pathogenesis of Kawasaki disease by network and pathway analysis.Computational and mathematical methods in medicine · 2013Review
- CD40 Gene polymorphisms associated with susceptibility and coronary artery lesions of Kawasaki disease in the Taiwanese population.TheScientificWorldJournal · 2012Article
- Augmented TLR2 expression on monocytes in both human Kawasaki disease and a mouse model of coronary arteritis.PloS one · 2012Article
- Transforming growth factor-beta signaling pathway in patients with Kawasaki disease.Circulation. Cardiovascular genetics · 2011Article
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To clarify the functional state of T cells in Kawasaki disease, we analysed mRNA expression levels of Th1/Th2 cytokines (IFN-gamma and IL-4) along with Th1/Th2-inducing transcription factors, T-bet and GATA-3, which play pivotal roles in the development of Th1 and Th2 cells, respectively. By real-time PCR, IFN-gamma mRNA levels in peripheral blood mononuclear cells (PBMNC) were significantly decreased in Kawasaki disease patients compared with those with measles, and tended to be lower than those in healthy controls. T-bet mRNA levels were significantly decreased in patients with Kawasaki disease compared with healthy controls. In addition, IL-4 and GATA-3 mRNA levels were significantly decreased in Kawasaki disease compared with healthy controls. Regulatory cytokine mRNA levels (TGF-beta and IL-10) were also decreased in Kawasaki disease. The mRNA levels of IFN-gamma showed a significant positive correlation with those of T-bet in Kawasaki disease. These results suggest that the suppressed function of Th1 and Th2, associated with the suppression of both T-bet and GATA-3 gene expression, may be one of the immunological characteristics of Kawasaki disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.