Evidence map›Paper›PMID 15270848›Full record

ArticleClinical and experimental immunology2004

Prevention of experimental autoimmune encephalomyelitis in DA rats by grafting primary skin fibroblasts engineered to express transforming growth factor-beta1.

T Zargarova, O Kulakova, V Prassolov, T Zharmukhamedova, V Tsyganova, V Turobov, D Ivanov, M Parfenov, M Sudomoina, Y Chernajovsky and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

T ZargarovaBranch of Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Russia.
O Kulakova
V Prassolov
T Zharmukhamedova
V Tsyganova
V Turobov
D Ivanov
M Parfenov
M Sudomoina
Y Chernajovsky
O Favorova
Pirogov Russian National Research Medical University · RUInstitute of Bioorganic Chemistry · RUQueen Mary University of London · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

To determine whether primary fibroblasts producing latent transforming growth factor beta1 (TGF-beta1) are capable of down-regulating experimental autoimmune encephalomyelitis (EAE), a retroviral vector TGF-beta1-pBabe-neo (-5'UTR) was used for efficient gene transfer into primary skin fibroblasts of DA rats. After heat activation, conditioned medium from the transduced fibroblasts was found to inhibit significantly in vitro proliferation of lymphocytes from lymph nodes of DA rats with EAE. Intraperitoneal administration of TGF-beta1-transduced fibroblasts into DA rats during the priming phase of EAE resulted in a significant reduction in mortality and in the mean clinical and EAE scores versus the control immunized animals treated with non-transduced fibroblasts.

Indexed as

AnimalsCell DivisionCulture Media, ConditionedEncephalomyelitis, Autoimmune, ExperimentalFibroblastsGenetic TherapyGenetic VectorsGene Transfer TechniquesLymphocyte ActivationRatsRetroviridaeReverse Transcriptase Polymerase Chain ReactionSkinT-LymphocytesTransforming Growth Factor betaTransforming Growth Factor beta1Culture Media, ConditionedTgfb1 protein, ratTransforming Growth Factor betaTransforming Growth Factor beta1

Identifiers

PMID15270848
PMCPMC1809117
OpenAlexW1996815163

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.