ArticleCell stress & chaperones2004
Serum and lymphocyte levels of heat shock protein 70 in aging: a study in the normal Chinese population.
Article in Cell stress & chaperones, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- Role of heat shock protein and cytokine expression as markers of clinical outcomes with glutamine-supplemented parenteral nutrition in surgical ICU patients.Clinical nutrition (Edinburgh, Scotland) · 2020Trial
- Sage tea drinking improves lipid profile and antioxidant defences in humans.International journal of molecular sciences · 2009Trial
- Proteostasis and ageing dissidence.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Indolylazine Derivative Induces Chaperone Expression in Aged Neural Cells and Prevents the Progression of Alzheimer's Disease.Molecules (Basel, Switzerland) · 2022Article
- Differential expression and regulation of HSP70 gene during growth phase in ruminants in response to heat stress.Scientific reports · 2022Article
- Former CSSI President Tangchun Wu elected to the Chinese Academy of Engineering.Cell stress & chaperones · 2022Article
- The increased expression of the inducible Hsp70 (HSP70A1A) in serum of patients with heart failure and its protective effect against the cardiotoxic agent doxorubicin.Molecular and cellular biochemistry · 2019Article
- Expression of cellular protective proteins SIRT1, HSP70 and SOD2 correlates with age and is significantly higher in NK cells of the oldest seniors.Immunity & ageing : I & A · 2017Article
- Effects of intracerebral hemorrhage and subsequent minimally invasive hematoma aspiration on expression of apoptosisrelated genes in rats.International journal of clinical and experimental pathology · 2015Article
- Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistance.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
- Genetic variations of HSPA1A, the heat shock protein levels, and risk of atherosclerosis.Cell stress & chaperones · 2012Article
- Comparison of hemodynamic, biochemical and hematological parameters of healthy pregnant women in the third trimester of pregnancy and the active labor phase.BMC pregnancy and childbirth · 2011Article
- Circulating heat shock protein 70 in health, aging and disease.BMC immunology · 2011Article
- Protein profile changes during porcine oocyte aging and effects of caffeine on protein expression patterns.PloS one · 2011Article
- Extracellular heat shock protein 70 (HSPA1A) and classical vascular risk factors in a general population.Cell stress & chaperones · 2010Article
- Increased circulating heat shock protein 70 levels in pregnant asthmatics.Cell stress & chaperones · 2010Article
- Circulating heat shock protein 70 (HSPA1A) in normal and pathological pregnancies.Cell stress & chaperones · 2010Review
- The level of Hsp27 in lymphocytes is negatively associated with a higher risk of lung cancer.Cell stress & chaperones · 2009Article
- Tissue-specific regulation and expression of heat shock proteins in type 2 diabetic monkeys.Cell stress & chaperones · 2009Article
- Using lymphocyte and plasma Hsp70 as biomarkers for assessing coke oven exposure among steel workers.Environmental health perspectives · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat shock proteins (Hsps) have been reported to play an important role in both physiological and pathological processes. Hsps also may serve as biomarkers for evaluating disease states and exposure to environmental stresses. Whether Hsp levels in serum and lymphocytes are correlated with age and sex is largely unknown. In this study, we analyzed serum Hsp70 (the most abundant mammalian Hsp) levels by using Western dot blot in 327 healthy male donors aged between 15 and 50 years. We also investigated the association between Hsp70 levels and age in lymphocytes of 80 normal individuals aged between 40 and 77 years because various chronic diseases increase after the age of 40 years. Our data showed that serum Hsp70 levels were positively correlated with age in subjects aged between 15 and 30 years (P < 0.05) but negatively correlated with age in subjects aged between 30 and 50 years (P < 0.05). Serum Hsp70 levels were the highest in individuals aged between 25 and 30 years among all age groups. In the lymphocyte study there also was a significant age-related decrease in Hsp70 levels in lymphocytes of individuals older than 40 years. The Hsp70 levels were negatively correlated with age (r = -3.708, P < 0.0001) but not with sex (r = -10.536, P = 0.452). This suggests that both serum and lymphocyte Hsp70 levels are age-related and that these may be linked to age-related stress. Thus, age is an important factor in using serum and lymphocyte Hsp70 as biomarkers to evaluate the disease states or exposure to environmental stresses (or both).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.