ArticleCell stress & chaperones2004
Mild heat stress stimulates 20S proteasome and its 11S activator in human fibroblasts undergoing aging in vitro.
Article in Cell stress & chaperones, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 62 citations in OpenAlex.
- Identification of resibufogenin, a component of toad venom, as a novel senolytic compound in vitro and for potential skin rejuvenation in male mice.Biogerontology · 2023Article
- Study on two nematode species suggests climate change will inflict greater crop damage.Scientific reports · 2023Article
- Skin Aging, Cellular Senescence and Natural Polyphenols.International journal of molecular sciences · 2021Review
- Female Mice Reaching Exceptionally High Old Age Have Preserved 20S Proteasome Activities.Antioxidants (Basel, Switzerland) · 2021Article
- Proteasome Biology: Chemistry and Bioengineering Insights.Polymers · 2020Review
- Aggregation and disaggregation features of the human proteome.Molecular systems biology · 2020Article
- Molecular Chaperones and Proteolytic Machineries Regulate Protein Homeostasis In Aging Cells.Cells · 2020Review
- Article
- Late-onset Alzheimer's disease, heating up and foxed by several proteins: pathomolecular effects of the aging process.Journal of Alzheimer's disease : JAD · 2014Article
- Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Hormesis-based anti-aging products: a case study of a novel cosmetic.Dose-response : a publication of International Hormesis Society · 2013Article
- Hormesis and Cellular Quality Control: A Possible Explanation for the Molecular Mechanisms that Underlie the Benefits of Mild Stress.Dose-response : a publication of International Hormesis Society · 2012Article
- Impairment of lon-induced protection against the accumulation of oxidized proteins in senescent wi-38 fibroblasts.The journals of gerontology. Series A, Biological sciences and medical sciences · 2011Article
- Basic leucine zipper protein Cnc-C is a substrate and transcriptional regulator of the Drosophila 26S proteasome.Molecular and cellular biology · 2011Article
- Multiple mild heat-shocks decrease the Gompertz component of mortality in Caenorhabditis elegans.Experimental gerontology · 2009Article
- Heat stress and hormetin-induced hormesis in human cells: effects on aging, wound healing, angiogenesis, and differentiation.Dose-response : a publication of International Hormesis Society · 2009Article
- Hormetic modulation of aging and longevity by mild heat stress.Dose-response : a publication of International Hormesis Society · 2006Article
- Anti-ageing strategies: prevention or therapy? Showing ageing from within.EMBO reports · 2005Article
- Proteasome activity or expression is not altered by activation of the heat shock transcription factor Hsf1 in cultured fibroblasts or myoblasts.Cell stress & chaperones · 2005Article
- Molecular mechanisms of anti-aging hormetic effects of mild heat stress on human cells.Nonlinearity in biology, toxicology, medicine · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Repeated mild heat shock (RMHS) has been shown to have several beneficial hormetic effects on human skin fibroblast undergoing aging in vitro. Because an age-related decline in proteasome activity is 1 of the reasons for the accumulation of abnormal proteins during aging, we have investigated the effects of RMHS on the 20S proteasome, which is the major proteolytic system involved in the removal of abnormal and oxidatively damaged proteins. Serially passaged human skin fibroblasts exposed to RMHS at 41 degrees C for 60 minutes twice a week had increased 3 proteasomal activities by 40% to 95% in early- and midpassage cultures. RMHS-treated cells also contained a 2-fold higher amount of the proteasome activator 11S, and the extent of the bound activator was double in early- and midpassage cells only. Furthermore, there was no difference in the content of the 19S proteasome regulator in the stressed and the unstressed cells. Therefore, RMHS-induced proteasome stimulation in early- and midpassage fibroblasts appears to be due to an induction and enhanced binding of 11S proteasome activators. In contrast to this, the proteasomal system in late-passage senescent cells appears to be less responsive to the stimulatory effects of mild heat shock.
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