ArticleThe Journal of molecular diagnostics : JMD2004
Allelic imbalance of 8p indicates poor survival in gastric cancer.
Article in The Journal of molecular diagnostics : JMD, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy.Oncotarget · 2015Review
- Genetic aspects of gastric cancer instability.TheScientificWorldJournal · 2012Review
- Clinicopathological and patient characteristics of early gastric neoplasia endoscopically resected with loss of Mlh1 expression.Oncology letters · 2011Article
- Prognostic significance of genetic alterations detected by high-density single nucleotide polymorphism array in gastric cancer.Cancer science · 2010Article
- Adrenal gland tumorigenesis after gonadectomy in mice is a complex genetic trait driven by epistatic loci.Endocrinology · 2008Article
- Cancer and forensic microsatellites.Forensic science, medicine, and pathology · 2008Review
- NF-κB and cancer: a paradigm of Yin-Yang.American journal of cancer researchArticle
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Gastric cancer is a common tumor worldwide and a tremendous health burden. However, the underlying mechanisms of tumorigenesis in this cancer's development are primarily undefined. Allelic imbalance (AI) of 8p has been reported in many cancers, yet, the target(s) of alteration and the importance of allelic imbalance on this chromosomal arm in gastric carcinoma development remained to be characterized. Our findings confirmed a high rate of AI on 8p in gastric cancers. Moreover, we demonstrated that AI on 8p, either overall or at marker D8S560, was associated with poorer survival in patients with gastric cancer. Finally, gastric cancers with a high rate of microsatellite instability were significantly associated with noncardia tumors and with female gender.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.