ArticleThe Journal of molecular diagnostics : JMD2004
Comparative genomic hybridization analysis of astrocytomas: prognostic and diagnostic implications.
Article in The Journal of molecular diagnostics : JMD, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Loss of Heterozygosity of 9p Is Associated with Poorer Survival in Patients with Gliomas.Molecular neurobiology · 2016Pooled it
- Integrated Genomics for Pinpointing Survival Loci within Arm-Level Somatic Copy Number Alterations.Cancer cell · 2016Article
- DNA copy number analysis of Grade II-III and Grade IV gliomas reveals differences in molecular ontogeny including chromothripsis associated with IDH mutation status.Acta neuropathologica communications · 2015Article
- MET gain in diffuse astrocytomas is associated with poorer outcome.Brain pathology (Zurich, Switzerland) · 2013Article
- Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma.The Journal of clinical investigation · 2012Article
- Biologic tumor behavior in pilocytic astrocytomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2012Article
- Deregulation of ion channel and transporter encoding genes in pediatric gliomas.Frontiers in oncology · 2012Article
- Intratumoral patterns of clonal evolution in gliomas.Neurogenetics · 2010Article
- Subtelomeric analysis of pediatric astrocytoma: subchromosomal instability is a distinctive feature of pleomorphic xanthoastrocytoma.Journal of neuro-oncology · 2009Article
- Early management of traumatic brain injury in a Tertiary hospital in Central Kenya: A clinical audit.Journal of neurosciences in rural practiceArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Astrocytoma is comprised of a group of common intracranial neoplasms that are classified into four grades based on the World Health Organization histological criteria and patient survival. To date, histological grade, patient age, and clinical performance, as reflected in the Karnofsky score, are the most reliable prognostic predictors. Recently, there has been a significant effort to identify additional prognostic markers using objective molecular genetic techniques. We believe that the identification of such markers will characterize new chromosomal loci important in astrocytoma progression and aid clinical diagnosis and prognosis. To this end, our laboratory used comparative genomic hybridization to identify DNA sequence copy number changes in 102 astrocytomas. Novel losses of 19p loci were detected in low-grade pilocytic astrocytomas and losses of loci on 9p, 10, and 22 along with gains on 7, 19, and 20 were detected in a significant proportion of high-grade astrocytomas. The Cox proportional hazards statistical modeling showed that the presence of +7q and -10q comparative genomic hybridization alterations significantly increased a patient's risk of dying, independent of histological grade. This investigation demonstrates the efficacy of comparative genomic hybridization for identifying tumor suppressor and oncogene loci in different astrocytic grades. The cumulative effect of these loci is an important consideration in their diagnostic and prognostic implications.
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Registered trials
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