ArticleMolecular biology of the cell2004
The essential role of PP1beta in Drosophila is to regulate nonmuscle myosin.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 68 citations in OpenAlex.
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- Roles for RNA export factor, Nxt1, in ensuring muscle integrity and normal RNA expression in Drosophila.G3 (Bethesda, Md.) · 2021Article
- Identification and functional analysis of five genes that encode distinct isoforms of protein phosphatase 1 in Nilaparvata lugens.Scientific reports · 2020Article
- Drosophila NUAK functions with Starvin/BAG3 in autophagic protein turnover.PLoS genetics · 2020Article
- Trpml controls actomyosin contractility and couples migration to phagocytosis in fly macrophages.The Journal of cell biology · 2020Article
- Tissue Fluidity Promotes Epithelial Wound Healing.Nature physics · 2019Article
- Actomyosin contractility modulates Wnt signaling through adherens junction stability.Molecular biology of the cell · 2019Article
- Suppression of epithelial folding at actomyosin-enriched compartment boundaries downstream of Wingless signalling inDevelopment (Cambridge, England) · 2018Article
- A dual role of the extracellular domain ofBiology open · 2018Article
- The emerging roles of phosphatases in Hedgehog pathway.Cell communication and signaling : CCS · 2017Review
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- A self-organized biomechanical network drives shape changes during tissue morphogenesis.Nature · 2015Article
- Elevated expression of the integrin-associated protein PINCH suppresses the defects of Drosophila melanogaster muscle hypercontraction mutants.PLoS genetics · 2013Article
- Protein phosphatase 1 β paralogs encode the zebrafish myosin phosphatase catalytic subunit.PloS one · 2013Article
- Protein phosphatase 1ß limits ring canal constriction during Drosophila germline cyst formation.PloS one · 2013Article
- Drosophila Psidin regulates olfactory neuron number and axon targeting through two distinct molecular mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Par-1 controls myosin-II activity through myosin phosphatase to regulate border cell migration.Current biology : CB · 2012Article
- Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling.Oncogene · 2011Article
- In vivo analysis of proteomes and interactomes using Parallel Affinity Capture (iPAC) coupled to mass spectrometry.Molecular & cellular proteomics : MCP · 2011Article
- Regulation of somatic myosin activity by protein phosphatase 1β controls Drosophila oocyte polarization.Development (Cambridge, England) · 2011Article
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8 authors at 1 institution in 1 country.
Funding
Abstract
Reversible phosphorylation of myosin regulatory light chain (MRLC) is a key regulatory mechanism controlling myosin activity and thus regulating the actin/myosin cytoskeleton. We show that Drosophila PP1beta, a specific isoform of serine/threonine protein phosphatase 1 (PP1), regulates nonmuscle myosin and that this is the essential role of PP1beta. Loss of PP1beta leads to increased levels of phosphorylated nonmuscle MRLC (Sqh) and actin disorganisation; these phenotypes can be suppressed by reducing the amount of active myosin. Drosophila has two nonmuscle myosin targeting subunits, one of which (MYPT-75D) resembles MYPT3, binds specifically to PP1beta, and activates PP1beta's Sqh phosphatase activity. Expression of a mutant form of MYPT-75D that is unable to bind PP1 results in elevation of Sqh phosphorylation in vivo and leads to phenotypes that can also be suppressed by reducing the amount of active myosin. The similarity between fly and human PP1beta and MYPT genes suggests this role may be conserved.
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