ArticleMolecular biology of the cell2004
Transcription profiling of cyclic AMP signaling in Candida albicans.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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Who cites it
88 citing papers in PubMed, 152 citations in OpenAlex.
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- A modified culture medium and hyphae isolation method can increase quality of the RNA extracted from mycelia of a dimorphic fungal species.Current genetics · 2021Article
- Integrative multi-omics profiling reveals cAMP-independent mechanisms regulating hyphal morphogenesis in Candida albicans.PLoS pathogens · 2021Article
- From Jekyll to Hyde: The Yeast-Hyphal Transition ofPathogens (Basel, Switzerland) · 2021Review
- Recording of DNA-binding events reveals the importance of a repurposed Candida albicans regulatory network for gut commensalism.Cell host & microbe · 2021Article
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- Systematic Analysis of Functionally Related Gene Clusters in the Opportunistic Pathogen,Microorganisms · 2021Article
- Transcriptomic and Metabolomic Analysis Revealed Roles of Yck2 in Carbon Metabolism and Morphogenesis ofFrontiers in cellular and infection microbiology · 2021Article
- Modulation of Immune Responses by Particle Size and Shape.Frontiers in immunology · 2020Review
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- Regulatory mechanisms controlling morphology and pathogenesis in Candida albicans.Current opinion in microbiology · 2019Review
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- Inhibition ofInternational journal of molecular sciences · 2019Article
- Circuit diversification in a biofilm regulatory network.PLoS pathogens · 2019Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used transcription profiling in Candida albicans to investigate cellular regulation involving cAMP. We found that many genes require the adenylyl cyclase Cdc35p for proper expression. These include genes encoding ribosomal subunit proteins and RNA polymerase subunit proteins, suggesting that growth could be controlled in part by cAMP-mediated modulation of gene expression. Other genes influenced by loss of adenylyl cyclase are involved in metabolism, the cell wall, and stress response and include a group of genes of unknown function that are unique to C. albicans. The profiles generated by loss of the adenylyl cyclase regulator Ras1p and a downstream effector Efg1p were also examined. The loss of Ras1p function disturbs the expression of a subset of the genes regulated by adenylyl cyclase, suggesting both that the primary role of Ras1p in transcriptional regulation involves its influence on the function of Cdc35p and that there are Ras1p independent roles for Cdc35p. The transcription factor Efg1p is also needed for the expression of many genes; however, these genes are distinct from those modulated by Cdc35p with the exception of a class of hyphal-specific genes. Therefore transcription profiling establishes that cAMP plays a key role in the overall regulation of gene expression in C. albicans, and enhances our detailed understanding of the circuitry controlling this regulation.
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