ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
cGMP-dependent kinase regulates response sensitivity of the mouse on bipolar cell.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 71 citations in OpenAlex.
- Review
- Nitric oxide modulates contrast suppression in a subset of mouse retinal ganglion cells.eLife · 2025Article
- Light Adaptation of Retinal Rod Bipolar Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Rod bipolar cells dysfunction occurs before ganglion cells loss in excitotoxin-damaged mouse retina.Cell death & disease · 2019Article
- Determination of basal phosphodiesterase activity in mouse rod photoreceptors with cGMP clamp.Scientific reports · 2019Article
- A Self-Regulating Gap Junction Network of Amacrine Cells Controls Nitric Oxide Release in the Retina.Neuron · 2018Article
- The Transduction Cascade in Retinal ON-Bipolar Cells: Signal Processing and Disease.Annual review of vision science · 2017Review
- Light-evoked S-nitrosylation in the retina.The Journal of comparative neurology · 2015Article
- PDE9A is expressed in the inner retina and contributes to the normal shape of the photopic ERG waveform.Frontiers in molecular neuroscience · 2014Article
- Nitric oxide modulates the temporal properties of the glutamate response in type 4 OFF bipolar cells.PloS one · 2014Article
- Nitric oxide mediates activity-dependent plasticity of retinal bipolar cell output via S-nitrosylation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Lateral interactions in the outer retina.Progress in retinal and eye research · 2012Review
- G-protein-mediated inhibition of the Trp channel TRPM1 requires the Gβγ dimer.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Defective retinal depolarizing bipolar cells in regulators of G protein signaling (RGS) 7 and 11 double null mice.The Journal of biological chemistry · 2012Article
- A role for nyctalopin, a small leucine-rich repeat protein, in localizing the TRP melastatin 1 channel to retinal depolarizing bipolar cell dendrites.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Expression pattern of Kv11 (Ether à-go-go-related gene; erg) K+ channels in the mouse retina.PloS one · 2011Article
- Stability of active zone components at the photoreceptor ribbon complex.Molecular vision · 2010Article
- TRPM1: the endpoint of the mGluR6 signal transduction cascade in retinal ON-bipolar cells.BioEssays : news and reviews in molecular, cellular and developmental biology · 2010Article
- Inhibition of nitric oxide synthase desensitizes retinal ganglion cells to light by diminishing their excitatory synaptic currents under light adaptation.Vision research · 2009Article
- Switching between transient and sustained signalling at the rod bipolar-AII amacrine cell synapse of the mouse retina.The Journal of physiology · 2009Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The visual system can adjust its sensitivity over a wide range of light intensities. Photoreceptors account for some of this adjustment, but there is evidence that postreceptoral processes also exist. To investigate the latter, we pharmacologically mimicked the effects of light stimulation on mouse On bipolar cells, thus avoiding confounding effects of receptoral mechanisms. Here, we report that cGMP selectively enhances responses to dim, but not bright, stimuli through a purely postsynaptic mechanism. This action of cGMP was completely blocked by inhibitors of cGMP-dependent kinase. We propose that cGMP-dependent kinase decreases coupling of the On bipolar cell glutamate receptor to the downstream cascade, thus amplifying small decreases in photoreceptor transmitter levels that would otherwise go undetected by the visual system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.