ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Corticotropin-releasing factor receptors CRF1 and CRF2 exert both additive and opposing influences on defensive startle behavior.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 124 citations in OpenAlex.
- Peripubertal antagonism of corticotropin-releasing factor receptor 1 results in sustained changes in behavioral plasticity and the transcriptomic profile of the amygdala.Neuroscience · 2025Article
- Peripubertal antagonism of corticotropin-releasing factor receptor 1 results in sustained changes in behavioral plasticity and the transcriptomic profile of the amygdala.bioRxiv : the preprint server for biology · 2025Article
- Sex-Specific changes in stress circuitry of the nucleus tractus solitarius following food deprivation in two rat strains.Neuroscience letters · 2024Article
- Prospective longitudinal assessment of sensorimotor gating as a risk/resiliency factor for posttraumatic stress disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Repeated norepinephrine receptor stimulation in the BNST induces sensorimotor gating deficits via corticotropin releasing factor.Neuropharmacology · 2020Article
- Orexin/hypocretin receptor modulation of anxiolytic and antidepressive responses during social stress and decision-making: Potential for therapy.Brain research · 2020Review
- Orexin 2 receptor stimulation enhances resilience, while orexin 2 inhibition promotes susceptibility, to social stress, anxiety and depression.Neuropharmacology · 2018Article
- Anti-stress neuropharmacological mechanisms and targets for addiction treatment: A translational framework.Neurobiology of stress · 2018Review
- Corticotropin-Releasing Factor Receptors Modulate Oxytocin Release in the Dorsolateral Bed Nucleus of the Stria Terminalis (BNST) in Male Rats.Frontiers in neuroscience · 2018Article
- Molecular and Cellular Effects of Traumatic Stress: Implications for PTSD.Current psychiatry reports · 2017Review
- Overexpression of Forebrain CRH During Early Life Increases Trauma Susceptibility in Adulthood.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Predator Stress-Induced CRF Release Causes Enduring Sensitization of Basolateral Amygdala Norepinephrine Systems that Promote PTSD-Like Startle Abnormalities.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Cell type-specific modifications of corticotropin-releasing factor (CRF) and its type 1 receptor (CRF1) on startle behavior and sensorimotor gating.Psychoneuroendocrinology · 2015Article
- Endogenous Opioids: The Downside of Opposing Stress.Neurobiology of stress · 2015Article
- Importance of CRF receptor-mediated mechanisms of the bed nucleus of the stria terminalis in the processing of anxiety and pain.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- CRF-R2 and the heterosynaptic regulation of VTA glutamate during reinstatement of cocaine seeking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Effects of intracerebroventricular corticotropin releasing factor on sensory-evoked responses in the rat visual thalamus.Brain research · 2014Article
- Forebrain-specific CRF overproduction during development is sufficient to induce enduring anxiety and startle abnormalities in adult mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Corticotropin-releasing factor peptide antagonists: design, characterization and potential clinical relevance.Frontiers in neuroendocrinology · 2014Review
- CRF1 receptor antagonists do not reverse pharmacological disruption of prepulse inhibition in rodents.Psychopharmacology · 2014Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The corticotropin-releasing factor (CRF) receptors (CRF1 and CRF2) are crucial mediators of physiological and behavioral responses to stress. In animals, CRF1 appears to primarily mediate CRF-induced anxiety-like responses, but the role of CRF2 during stress is still unclear. Here we report the effects of CRF1 and CRF2 on the magnitude and plasticity of defensive startle responses in mice. Startle plasticity is measured by inhibition of startle by sensory stimuli, i.e., prepulse inhibition (PPI), and is disrupted in patients with panic or posttraumatic stress disorders in which CRF neurotransmission may be overactive. Pharmacological blockade of CRF1 reversed both CRF-induced increases in startle and CRF-induced deficits in PPI. CRF2 blockade attenuated high-dose but not low-dose CRF-induced increases in startle and reduced PPI. Conversely, activation of CRF2 enhanced PPI. CRF had no effect on startle and increased PPI in CRF1 knock-out mice. These data indicate that CRF receptors act in concert to increase the magnitude of defensive startle yet in opposition to regulate the flexibility of startle. These data support a new model of respective CRF receptor roles in stress-related behavior such that, although both receptors enhance the magnitude of defensive responses, CRF1 receptors contravene, whereas CRF2 receptors enhance, the impact of sensory information on defensive behavior. We hypothesize that excessive CRF1 activation combined with reduced CRF2 signaling may contribute to information processing deficits seen in panic and posttraumatic stress disorder patients and support CRF1-specific pharmacotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.