ArticleArchives of disease in childhood2004
Presentation of vitamin D deficiency.
Article in Archives of disease in childhood, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
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Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 256 citations in OpenAlex.
- Serum 25-hydroxyvitamin D threshold and risk of rickets in young children: a systematic review and individual participant data meta-analysis to inform the development of dietary requirements for vitamin D.European journal of nutrition · 2024Pooled it
- Trial
- Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Trial
- Article
- Vitamin D in the UK: an urgent call to redefine the threshold for deficiency.Frontiers in endocrinology · 2026Review
- A comparative study of hormonal contraceptive use and vitamin D levels at Gondar Town 2023.Scientific reports · 2024Article
- Nutritional rickets presenting with developmental regression: a rare presentation of rickets.BMC pediatrics · 2023Article
- Vitamin D Deficiency in Chronic Childhood Disorders: Importance of Screening and Prevention.Nutrients · 2023Review
- Mineral Metabolism in Children: Interrelation between Vitamin D and FGF23.International journal of molecular sciences · 2023Review
- Total Usual Nutrient Intakes and Nutritional Status of United Arab Emirates Children (<4 Years): Findings from the Feeding Infants and Toddlers Study (FITS) 2021.Current developments in nutrition · 2022Article
- Nutritional status and adequacy of feeding Practices in Infants and Toddlers 0-23.9 months living in the United Arab Emirates (UAE): findings from the feeding Infants and Toddlers Study (FITS) 2020.BMC public health · 2022Article
- The burden of vitamin D deficiency in household members of children presenting with symptomatic vitamin D deficiency.Frontiers in endocrinology · 2022Article
- Severe Symptomatic Vitamin D Deficiency During COVID-19 "Stay at-Home-Orders" in New York City.Global pediatric health · 2022Article
- Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter StudyJournal of clinical research in pediatric endocrinology · 2021Article
- White enamel lesions in children: considering caries, chronological and congenital causes and their consequent care.British dental journal · 2021Article
- Article
- Nutritional rickets & osteomalacia: A practical approach to management.The Indian journal of medical research · 2020Review
- Vitamin D level and its relation to muscle and fat mass in adult male Arabs.Saudi journal of biological sciences · 2020Article
- Article
- Micronutrient deficiencies and health-related quality of life: the case of children with vitamin D deficiency.Public health nutrition · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo describe the various ways in which vitamin D deficiency presents in children in selected districts of London and to identify which factors, if any, determine the mode of presentation.
methodsRetrospective review of patients presenting to Newham General, Royal London, Great Ormond Street, and King's College Hospitals between 1996 and 2001 with either hypocalcaemia or rickets caused by vitamin D deficiency. Children with plasma 25-hydroxyvitamin D levels <25 nmol/l (10 ng/ml) were considered to have vitamin D deficiency.
resultsSixty five children, mostly from Black or Asian ethnic minority groups, were identified, 29 of whom had hypocalcaemic symptoms. Seventeen of these had no radiological evidence of rickets. The remainder (48 children) had radiological evidence of rickets with or without clinical signs. Symptoms and signs reverted to normal in all cases with vitamin D supplementation. All children who presented with symptomatic hypocalcaemia were aged either <3 or >10 years. There was a strong correlation between age at presentation and population growth velocity reference data.
conclusionsRickets remains a problem in the UK especially in "at risk" ethnic minority groups. Symptomatic hypocalcaemia is an important, but under-recognised presenting feature. Growth rate is likely to be an important factor in determining the mode of presentation. Unexplained hypocalcaemia should be attributed to vitamin D deficiency in "at risk" ethnic minority groups until proved otherwise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.