ReviewAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2004
RNA interference: a potent tool for gene-specific therapeutics.
Review in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 105 citations in OpenAlex.
- Shaker potassium channel mediates an age-sensitive neurocardiac axis regulating sleep and cardiac function in Drosophila.Biogerontology · 2026Article
- Nebulized milk exosomes loaded with siTGF-β1 ameliorate pulmonary fibrosis by inhibiting EMT pathway and enhancing collagen permeability.Journal of nanobiotechnology · 2024Article
- Lentivirus-mediated RNA interference targeting HMGB1 modulates AQP1 to reduce pain induced by chronic compression of the dorsal root ganglia.Frontiers in pharmacology · 2024Article
- Nanoparticles design considerations to co-deliver nucleic acids and anti-cancer drugs for chemoresistance reversal.International journal of pharmaceutics: X · 2022Article
- Small Interfering RNA for Gliomas Treatment: Overcoming Hurdles in Delivery.Frontiers in cell and developmental biology · 2022Review
- SMRI: A New Method for siRNA Design for COVID-19 Therapy.Journal of computer science and technology · 2022Article
- Gene Therapy in Orthopaedics: Progress and Challenges in Pre-Clinical Development and Translation.Frontiers in bioengineering and biotechnology · 2022Review
- In vivo self-assembled small RNAs as a new generation of RNAi therapeutics.Cell research · 2021Article
- The function of lncRNAs in the pathogenesis of osteoarthritis.Bone & joint research · 2021Article
- Lentiviral‑mediated inducible silencing of TLR4 attenuates neuropathic pain in a rat model of chronic constriction injury.Molecular medicine reports · 2018Article
- lncRNAs: novel players in intervertebral disc degeneration and osteoarthritis.Cell proliferation · 2017Review
- Small interfering RNA targeting TNF-α gene significantly attenuates renal ischemia-reperfusion injury in mice.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2016Article
- Silencing c-Kit expression in human DCs suppresses Th2, Th17 response but enhances Th1 response.American journal of translational research · 2015Article
- Positive and Negative Regulation of Th17 Cell Differentiation: Evaluating The Impact of RORC2.Cell journal · 2014Article
- Lentivirus mediated siRNA against GluN2B subunit of NMDA receptor reduces nociception in a rat model of neuropathic pain.BioMed research international · 2014Article
- siRNA Delivery Improvement by Co-formulation of Different Modified Polymers in Erythroleukemic Cell Line K562.Iranian journal of basic medical sciences · 2013Article
- Combinatorial gene targeting hTERT and BI-1 in CNE-2 nasopharyngeal carcinoma cell line.Biomedical reports · 2013Article
- RORC2 gene silencing in human Th17 cells by siRNA: design and evaluation of highly efficient siRNA.Avicenna journal of medical biotechnology · 2013Article
- Personalized cancer approach: using RNA interference technology.World journal of surgery · 2011Review
- Prevention of hyperglycemia-induced myocardial apoptosis by gene silencing of Toll-like receptor-4.Journal of translational medicine · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA interference (RNAi) is a process through which double-stranded RNA induces the activation of cellular pathways, leading to potent and selective silencing of genes with homology to the double strand. Much excitement surrounding small interfering RNA (siRNA)-mediated therapeutics arises from the fact that this approach overcomes many of the shortcomings previously experienced with approaches such as antibodies, antisense oligonucleotides and pharmacological inhibitors. Induction of RNAi through administration of siRNA has been successfully used in treatment of hepatitis, viral infections, and cancer. In this review we will present a brief history of RNAi, methods of inducing RNAi, application of RNAi in the therapeutic setting, and the possibilities of using this highly promising approach in the context of transplantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.