SynthesisThe Cochrane database of systematic reviews2004
Maintenance therapy with calcium channel blockers for preventing preterm birth after threatened preterm labour.
Synthesis in The Cochrane database of systematic reviews, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 5 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Maintenance therapy with calcium channel blockers for preventing preterm birth after threatened preterm labour.The Cochrane database of systematic reviews · 2013Pooled it
- Maintenance therapy with oxytocin antagonists for inhibiting preterm birth after threatened preterm labour.The Cochrane database of systematic reviews · 2013Pooled it
- Magnesium maintenance therapy for preventing preterm birth after threatened preterm labour.The Cochrane database of systematic reviews · 2013Pooled it
- Oral betamimetics for maintenance therapy after threatened preterm labour.The Cochrane database of systematic reviews · 2012Pooled it
- Nifedipine in the management of preterm labor: a systematic review and metaanalysis.American journal of obstetrics and gynecology · 2011Pooled it
- Assessment of perinatal outcome after sustained tocolysis in early labour (APOSTEL-II trial).BMC pregnancy and childbirth · 2009Trial
- Ritodrine in oral maintenance of tocolysis after active preterm labor: randomized controlled trial.Croatian medical journal · 2006Trial
- Article
- High prevalence of hypovitaminosis D in pregnant Japanese women with threatened premature delivery.Journal of bone and mineral metabolism · 2011Article
- Care for women with prior preterm birth.American journal of obstetrics and gynecology · 2010Review
- Evidence for perinatal and child health care guidelines in crisis settings: can Cochrane help?BMC public health · 2010Article
- Association between vitamin D deficiency and primary cesarean section.The Journal of clinical endocrinology and metabolism · 2009Article
Corrections and comments
- Updated by
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCalcium channel blocker maintenance therapy is one of the types of tocolytic therapy used after an episode of threatened preterm labour (and usually an initial dose of tocolytic therapy) in an attempt to prevent the onset of further preterm contractions.
objectivesTo assess the effects of calcium channel blockers as maintenance therapy on preventing preterm birth after threatened preterm labour. SEARCH STRATEGY: We searched the Cochrane Pregnancy and Childbirth Group trials register (31 March 2004); MEDLINE (1966 to March 2004) and DARE (June 2003). SELECTION CRITERIA: Randomised controlled trials of calcium channel blockers used as maintenance therapy to prevent preterm birth after threatened preterm labour, compared with alternative drug therapy, placebo or no treatment. DATA COLLECTION AND ANALYSIS: Two reviewers independently applied the selection criteria, extracted data from the included study and assessed study quality. MAIN
resultsOne trial of 74 women was included. No difference in the incidence of preterm birth was found when calcium channel blocker (nifedipine) maintenance therapy was compared with no treatment. Twenty-five women out of 37 in each group gave birth before 37 weeks (relative risk 1.00, 95% confidence interval 0.73 to 1.37). The trial did not report stillbirths and neonatal deaths prior to discharge. Neurological follow up of the infants was not addressed. REVIEWERS'
conclusionsThe role of maintenance therapy with calcium channel blockers for preventing preterm birth is not clear. Well designed randomised trials of sufficient size with relevant outcomes are required.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.