Evidence map›Paper›PMID 15266330›Full record

ArticleBritish journal of cancer2004

Papillary carcinoma of the thyroid: methylation is not involved in the regulation of MET expression.

S Scarpino, A Di Napoli, M Rapazzotti-Onelli, E Pilozzi, L Ruco

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

S ScarpinoDipartimento di Diagnostica di Laboratorio e Patologia, II Facoltà di Medicina e Chirurgia, Ospedale Sant'Andrea, Via di Grottarossa 1035-1039, 00189 Università 'La Sapienza', Rome, Italy. stefania.scarpino@uniromal.it
A Di Napoli
M Rapazzotti-Onelli
E Pilozzi
L Ruco
Azienda Ospedaliera Sant'Andrea · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypomethylation has been reported to be responsible for the activation of several oncogenes. The possibility that hypomethylation is involved in the regulation of MET transcription was investigated through the analysis of the methylation status of one CpG island containing 43 CpGs in six cases of papillary carcinoma, in the corresponding normal thyroid tissue, and in two cases of hyperplastic goitre. Evidence of methylation was not found in any of the analysed CpG.

Indexed as

DNA MethylationGene Expression Regulation, NeoplasticProtein BiosynthesisReceptors, Growth FactorAdultAgedCarcinoma, PapillaryCpG IslandsDNA, NeoplasmFemaleHumansImmunohistochemistryMaleMiddle AgedPromoter Regions, GeneticProto-Oncogene ProteinsDNA, NeoplasmMET protein, humanProto-Oncogene ProteinsProto-Oncogene Proteins c-metReceptors, Growth Factor

Identifiers

PMID15266330
PMCPMC2364796
OpenAlexW2040469647

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.