Evidence map›Paper›PMID 15266308›Full record

Trial reportEuropean journal of clinical nutrition2005

Immunoenhanced enteral nutrition, effect on inflammatory markers in head and neck cancer patients.

D A de Luis, M Arranz, R Aller, O Izaola, L Cuellar, M C Terroba

Registry-linked trialOpen access · bronzeAbstract readClinical TrialRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00333099 (Effect of Enteral Immunonutrition During Chemoradiotherapy in Patients With Head and Neck Cancer or Esophageal Cancer), which is not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00333099 phase4completednot on this mapstarted 2006, after this paper: background citation

Effect of Enteral Immunonutrition During Chemoradiotherapy in Patients With Head and Neck Cancer or Esophageal Cancer

TypeinterventionalSponsorUniversity Hospital, Clermont-FerrandRan2006 to 2011Enrolled250ConditionsMalnutrition, Esophageal Cancer, Head and Neck CancerArmsImpact (R) Enteral Nutrition, impact
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. The impact of immunonutrition in head and neck cancer surgery: a systematic review with meta-analysis.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2025
    Pooled it
  2. Immunonutrition for patients undergoing surgery for head and neck cancer.The Cochrane database of systematic reviews · 2018
    Pooled it
  3. Trial
  4. Immunonutrition before and during radiochemotherapy: improvement of inflammatory parameters in head and neck cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2012
    Trial
  5. Trial
  6. Arginine-supplemented enteral nutrition.Journal of cancer research and clinical oncology · 2014
    Article
  7. Review
  8. Nutritional immunomodulation of acute pancreatitis.Current gastroenterology reports · 2007
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

D A de LuisInstitute of Endocrinology and Nutrition, Medicine School and Unit of Investigation Hospital Rio Hortega, Spain. Dadluis@yahoo.es
M Arranz
R Aller
O Izaola
L Cuellar
M C Terroba
Hospital Universitario Río Hortega · ESHospital Clínico Universitario de Valladolid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of our study was to evaluate the effect of enteral nutrition supplemented with arginine in inflammatory markers in surgical head and neck cancer patients. A population of 29 patients with oral and laryngeal cancer were enrolled in a randomized trial. At surgery patients were randomly allocated to two groups: (a) patients receiving an enteral diet supplements with arginine (group I, n=14); (b) patients receiving an isocaloric, isonitrogenous enteral formula (group II, n=15). The mean age was 61.1+/-10.8 y (five females/24 males). Characteristics of the patients on enrollment were similar for the two groups. Prealbumin and transferrin improved in both groups. c-reactive protein (CRP) levels decreased in both groups, (group I: 134.5+/-62.5 vs 75.3+/-51 mg/dl:P<0.05) and (group II: 103.6+/-62 vs 43.8+/-34.4 mg/dl:P<0.05). Interleukin-6 (IL-6) improved in both groups (group I: 20.35+/-11.2 vs 6.7+/-3.1 pg/ml:P<0.05) and (group II:22.8+/-40 vs 9.9+/-17.7 pg/ml:ns). Tumoral necrosis factor alpha and lymphocytes did not change. In conclusion, both formulas improved IL-6 and CRP levels. Further studies are needed to determine whether type of formula is the key in these patients or genetic background play a main role in inflammatory response.

Indexed as

Enteral NutritionArginineC-Reactive ProteinFemaleHead and Neck NeoplasmsHumansImmunotherapyInterleukin-6LymphocytesMaleMiddle AgedPostoperative CareTreatment OutcomeTumor Necrosis Factor-alphaArginineC-Reactive ProteinInterleukin-6Tumor Necrosis Factor-alpha

Identifiers

PMID15266308
OpenAlexW1972390062

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.