ArticleBMC nephrology2004
Effects of chemokines on proliferation and apoptosis of human mesangial cells.
Article in BMC nephrology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 46 citations in OpenAlex.
- Endogenous IL-33 inhibits apoptosis in non-small cell lung cancer cells by regulating BCL2/BAX via the ERK1/2 pathway.Scientific reports · 2025Article
- Emerging roles of a chemoattractant receptor GPR15 and ligands in pathophysiology.Frontiers in immunology · 2023Review
- Role of Chemokine (C-X-C Motif) Ligand 10 (CXCL10) in Renal Diseases.Mediators of inflammation · 2020Review
- Cell Death in the Kidney.International journal of molecular sciences · 2019Review
- Rosiglitazone blocks first trimester in-vitro placental injury caused by NF-κB-mediated inflammation.Scientific reports · 2019Article
- CCR7 Is Important for Mesangial Cell Physiology and Repair.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2018Article
- Non-canonical NFκB activation promotes chemokine expression in podocytes.Scientific reports · 2016Article
- Increased CCL19 and CCL21 levels promote fibroblast ossification in ankylosing spondylitis hip ligament tissue.BMC musculoskeletal disorders · 2014Article
- Hepatitis C virus induced endothelial inflammatory response depends on the functional expression of TNFα receptor subtype 2.PloS one · 2014Article
- Interleukin 7 signaling prevents apoptosis by regulating bcl-2 and bax via the p53 pathway in human non-small cell lung cancer cells.International journal of clinical and experimental pathology · 2014Article
- CCL21/CCR7 prevents apoptosis via the ERK pathway in human non-small cell lung cancer cells.PloS one · 2012Article
- Maternal undernourished fetal kidneys exhibit differential regulation of nephrogenic genes including downregulation of the Notch signaling pathway.Reproductive sciences (Thousand Oaks, Calif.) · 2011Article
- CCL21/CCR7 promotes G2/M phase progression via the ERK pathway in human non-small cell lung cancer cells.PloS one · 2011Article
- Association between decreased CXCL12 and CCL25 expression and increased apoptosis in lymphoid tissues of cynomolgus macaques during SIV infection.Journal of medical primatology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProliferation and apoptosis of mesangial cells (MC) are important mechanisms during nephrogenesis, for the maintenance of glomerular homeostasis as well as in renal disease and glomerular regeneration. Expression of chemokines and chemokine receptors by intrinsic renal cells, e.g. SLC/CCL21 on podocytes and CCR7 on MC is suggested to play a pivotal role during these processes. Therefore the effect of selected chemokines on MC proliferation and apoptosis was studied.
methodsProliferation assays, cell death assays including cell cycle analysis, hoechst stain and measurement of caspase-3 activity were performed.
resultsA dose-dependent, mesangioproliferative effect of the chemokine SLC/CCL21, which is constitutively expressed on human podocytes was seen via activation of the chemokine receptor CCR7, which is constitutively expressed on MC. In addition, in cultured MC SLC/CCL21 had a protective effect on cell survival in Fas-mediated apoptosis. The CXCR3 ligands IP-10/CXCL10 and Mig/CXCL9 revealed a proproliferative effect but did not influence apoptosis of MC. Both the CCR1 ligand RANTES/CCL5 and the amino-terminally modified RANTES analogue Met-RANTES which blocks CCR1 signalling had no effect on proliferation and apoptosis.
conclusionsThe different effects of chemokines and their respective receptors on proliferation and apoptosis of MC suggest highly regulated, novel biological functions of chemokine/chemokine receptor pairs in processes involved in renal inflammation, regeneration and glomerular homeostasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.