ArticleBMC cancer2004
Identification of astrocytoma associated genes including cell surface markers.
Article in BMC cancer, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- Signature Genes Selection and Functional Analysis of Astrocytoma Phenotypes: A Comparative Study.Cancers · 2024Article
- Collagen VI sustains cell stemness and chemotherapy resistance in glioblastoma.Cellular and molecular life sciences : CMLS · 2023Article
- Aquaporins in Nervous System.Advances in experimental medicine and biology · 2023Article
- DNA Methylation Analysis Identifies Patterns in Progressive Glioma Grades to Predict Patient Survival.International journal of molecular sciences · 2021Article
- Prognostic Potential of Secreted Modular Calcium-Binding Protein 1 in Low-Grade Glioma.Frontiers in molecular biosciences · 2021Article
- Secreted modular calcium-binding proteins in pathophysiological processes and embryonic development.Chinese medical journal · 2019Review
- SMOC1 silencing suppresses the angiotensin II-induced myocardial fibrosis of mouse myocardial fibroblasts via affecting the BMP2/Smad pathway.Oncology letters · 2018Article
- Collagen VI in healthy and diseased nervous system.Disease models & mechanisms · 2018Review
- Aquaporins and Brain Tumors.International journal of molecular sciences · 2016Review
- The deadly connection between endoplasmic reticulum, Ca2+, protein synthesis, and the endoplasmic reticulum stress response in malignant glioma cells.Neuro-oncology · 2014Article
- Identification of death receptors DR4 and DR5 in HTB-12 astrocytoma cell lines and determination of TRAIL sensitivity.Journal of solid tumors · 2013Article
- Article
- A Prevalence of Imprinted Genes within the Total Transcriptomes of Human Tissues and Cells.Molecular biology international · 2012Article
- Identification of transcriptional regulatory networks specific to pilocytic astrocytoma.BMC medical genomics · 2011Article
- In-depth global analysis of transcript abundance levels in porcine alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus.Advances in virology · 2010Article
- Nitric oxide inhibits glomerular TGF-beta signaling via SMOC-1.Journal of the American Society of Nephrology : JASN · 2009Article
- Gene expression profiling of human neural progenitor cells following the serum-induced astrocyte differentiation.Cellular and molecular neurobiology · 2009Article
- The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility.The Journal of biological chemistry · 2008Article
- BEHAB/brevican requires ADAMTS-mediated proteolytic cleavage to promote glioma invasion.Journal of neuro-oncology · 2008Article
- Aquaporins--new players in cancer biology.Journal of molecular medicine (Berlin, Germany) · 2008Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDespite intense effort the treatment options for the invasive astrocytic tumors are still limited to surgery and radiation therapy, with chemotherapy showing little or no increase in survival. The generation of Serial Analysis of Gene Expression (SAGE) profiles is expected to aid in the identification of astrocytoma-associated genes and highly expressed cell surface genes as molecular therapeutic targets. SAGE tag counts can be easily added to public expression databases and quickly disseminated to research efforts worldwide.
methodsWe generated and analyzed the SAGE transcription profiles of 25 primary grade II, III and IV astrocytomas 1. These profiles were produced as part of the Cancer Genome Anatomy Project's SAGE Genie 2, and were used in an in silico search for candidate therapeutic targets by comparing astrocytoma to normal brain transcription. Real-time PCR and immunohistochemistry were used for the validation of selected candidate target genes in 2 independent sets of primary tumors.
resultsA restricted set of tumor-associated genes was identified for each grade that included genes not previously associated with astrocytomas (e.g. VCAM1, SMOC1, and thymidylate synthetase), with a high percentage of cell surface genes. Two genes with available antibodies, Aquaporin 1 and Topoisomerase 2A, showed protein expression consistent with transcript level predictions.
conclusionsThis survey of transcription in malignant and normal brain tissues reveals a small subset of human genes that are activated in malignant astrocytomas. In addition to providing insights into pathway biology, we have revealed and quantified expression for a significant portion of cell surface and extra-cellular astrocytoma genes.
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