Trial reportMolecular psychiatry2004
Variations in estrogen receptor alpha gene and risk of dementia, and brain volumes on MRI.
Trial report in Molecular psychiatry, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Meta-analysis of the association between polymorphisms of estrogen receptor α genes rs9340799 and rs2234693 and Alzheimer's disease: evidence from 23 articles.American journal of Alzheimer's disease and other dementias · 2014Pooled it
- Estrogen receptor α gene polymorphisms and risk of Alzheimer's disease: evidence from a meta-analysis.Clinical interventions in aging · 2014Pooled it
- Effects of Sex Steroids in the Human Brain.Molecular neurobiology · 2017Review
- Pathomechanisms of atrophy in insular cortex in Alzheimer's disease.American journal of Alzheimer's disease and other dementias · 2015Article
- Common variants in psychiatric risk genes predict brain structure at birth.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- Article
- Understanding Youth Antisocial Behavior Using Neuroscience through a Developmental Psychopathology Lens: Review, Integration, and Directions for Research.Developmental review : DR · 2013Article
- The Rotterdam Study: 2012 objectives and design update.European journal of epidemiology · 2011Article
- A review of estrogen receptor alpha gene (ESR1) polymorphisms, mood, and cognition.Menopause (New York, N.Y.) · 2010Review
- The Rotterdam Study: 2010 objectives and design update.European journal of epidemiology · 2009Article
- Sex steroid-related candidate genes in psychiatric disorders.Journal of psychiatry & neuroscience : JPN · 2008Review
- Hormonal treatment, mild cognitive impairment and Alzheimer's disease.International psychogeriatrics · 2008Review
- Estrogen receptor-alpha variants increase risk of Alzheimer's disease in women with Down syndrome.Dementia and geriatric cognitive disorders · 2008Article
- Interaction between estrogen receptor-alpha and butyrylcholinesterase genes modulates Alzheimer's disease risk.Journal of neurology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of estrogens in Alzheimer's disease (AD) is controversial. We investigated the association between well-recognized, and potentially functional, polymorphisms in the estrogen receptor (ER) alpha gene and the risk of AD in a prospective study of 6056 Caucasian older men and women aged 55 years and over. In a subset of 468 participants, we assessed volumes of the hippocampus and amygdala, which have a high density of ER alpha, with brain magnetic resonance imaging (MRI) (1.5 T MR unit). During a total of 35 405 person-years of follow-up (mean per persons 5.8 years), 312 new cases of dementia were detected, of whom 230 were diagnosed with AD. Neither the PvuII nor the XbaI polymorphism or haplotypes thereof were associated with the risk of all-cause dementia or AD. In contrast, we found that nondemented women who carried the PvuII p allele or haplotype 'px' had smaller amygdalar volumes on MRI in an allele-dose-dependent fashion. Total amygdalar volume was 4.50 (SE 0.10) in PP genotype, 4.45 (SE 0.06) in Pp genotype, and 4.18 ml (SE 0.08) in pp genotype (P trend=0.008). Further studies are required to investigate whether this smaller amygdalar volume has functional significance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.