ReviewCurrent psychiatry reports2004
The genes for schizophrenia: finally a breakthrough?
Review in Current psychiatry reports, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Pooled it
- Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples.Biological psychiatry · 2006Pooled it
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- Association study of neuregulin-1 gene polymorphisms in a North Indian schizophrenia sample.Schizophrenia research · 2013Article
- Genetic association studies of antioxidant pathway genes and schizophrenia.Antioxidants & redox signaling · 2011Review
- Oxidative stress in schizophrenia: pathogenetic and therapeutic implications.Antioxidants & redox signaling · 2011Article
- Candidate genes and their interactions with other genetic/environmental risk factors in the etiology of schizophrenia.Brain research bulletin · 2010Review
- Functional MRI at the crossroads.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2009Article
- Linkage analysis of schizophrenia in African-American families.Schizophrenia research · 2009Article
- Linkage disequilibrium patterns and functional analysis of RGS4 polymorphisms in relation to schizophrenia.Schizophrenia bulletin · 2008Article
- Dopamine genes and schizophrenia: case closed or evidence pending?Schizophrenia bulletin · 2007Review
- How a neuropsychiatric brain bank should be run: a consensus paper of Brainnet Europe II.Journal of neural transmission (Vienna, Austria : 1996) · 2007Article
- Schizophrenia in translation: disrupted in schizophrenia (DISC1): integrating clinical and basic findings.Schizophrenia bulletin · 2007Review
- Can RGS4 polymorphisms be viewed as credible risk factors for schizophrenia? A critical review of the evidence.Schizophrenia bulletin · 2006Review
- Linkage analysis of a completely ascertained sample of familial schizophrenics and bipolars from Palau, Micronesia.Human genetics · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A number of susceptibility genes for schizophrenia have recently been identified. They have engendered excitement because replicate studies have attained greater consistency than in the past. In this review, we outline gene mapping methods, and briefly review their strengths and challenges. We also evaluate peer-reviewed genetic association studies that have implicated six selected genes: catechol-O-methyl transferase (COMT), neuregulin 1 (NRG1), dysbindin (DTNBP1), regulator of G-protein signaling 4 (RGS4), and G72 and D-amino-acid oxidase (DAAO). The available supporting evidence is variable. Though credible evidence is available for all of these genes, it is strongest for NRG1 and DTNBP1. Further studies, particularly exhaustive analyses of all polymorphisms at each locus, meta-analyses, and investigations of the likely function of risk alleles (variants) are desirable.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.