ArticleWorld journal of gastroenterology2004
Increased oxidative DNA damage, inducible nitric oxide synthase, nuclear factor kappaB expression and enhanced antiapoptosis-related proteins in Helicobacter pylori-infected non-cardiac gastric adenocarcinoma.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 51 citations in OpenAlex.
- Effect of Rebamipide on the Premalignant Progression of Chronic Gastritis: A Randomized Controlled Study.Clinical drug investigation · 2015Trial
- Revisiting Curcumin in Cancer Therapy: Recent Insights into Molecular Mechanisms, Nanoformulations, and Synergistic Combinations.Current issues in molecular biology · 2025Review
- Article
- NF-κB in Gastric Cancer Development and Therapy.Biomedicines · 2021Review
- Manifold role of ubiquitin in Helicobacter pylori infection and gastric cancer.Cellular and molecular life sciences : CMLS · 2021Review
- Tampering of Viruses and Bacteria with Host DNA Repair: Implications for Cellular Transformation.Cancers · 2021Review
- H. pylori infection confers resistance to apoptosis via Brd4-dependent BIRC3 eRNA synthesis.Cell death & disease · 2020Article
- The genetic association betweenOncoTargets and therapy · 2018Article
- Inducible Nitric Oxide Synthase in the Carcinogenesis of Gastrointestinal Cancers.Antioxidants & redox signaling · 2017Review
- Article
- Relation between gastric cancer and protein oxidation, DNA damage, and lipid peroxidation.Oxidative medicine and cellular longevity · 2013Article
- Effects of different Helicobacter pylori culture filtrates on growth of gastric epithelial cells.World journal of gastroenterology · 2008Article
- Upregulation of cIAP2 in regenerating colonocytes in ulcerative colitis.Virchows Archiv : an international journal of pathology · 2007Article
- UvrD helicase suppresses recombination and DNA damage-induced deletions.Journal of bacteriology · 2006Article
- Latest insights into the effects of Helicobacter pylori infection on gastric carcinogenesis.World journal of gastroenterology · 2006Review
- Differences in oxidative stress dependence between gastric adenocarcinoma subtypes.World journal of gastroenterology · 2006Article
- Role of the nrf-2 gene in protection and repair of gastric mucosa against oxidative stress.Inflammopharmacology · 2005Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimSeveral epidemiological studies have demonstrated a close association between Helicobacter pylori (H pylori) infection and non-cardiac carcinoma of the stomach. H pylori infection induces active inflammation with neutrophilic infiltrations as well as production of oxygen free radicals that can cause DNA damage. The DNA damage induced by oxygen free radicals could have very harmful consequences, leading to gene modifications that are potentially mutagenic and/or carcinogenic. The aims of the present study were to assess the effect of H pylori infection on the expression of inducible nitric oxidative synthase (iNOS) and the production of 8-hydroxy-deoxyguanosine (8-OHdG), a sensitive marker of oxidative DNA injury in human gastric mucosa with and without tumor lesions, and to assess the possible factors affecting cell death signaling due to oxidative DNA damage.
methodsIn this study, 40 gastric carcinoma specimens and adjacent specimens were obtained from surgical resection. We determined the level of 8-OHdG formation by HPLC-ECD, and the expression of iNOS and mechanism of cell death signaling (including nuclear factor-kappaB(NFkappaB), MEKK-1, Caspase 3, B Cell lymphomal leukemia-2 (Bcl-2), inhibitor of apoptosis protein (IAP) and myeloid cell leukemia-1 (Mcl-1)) by Western-blot assay.
resultsThe concentrations of 8-OHdG, iNOS, NFkappaB, Mcl-1 and IAP were significantly higher in cancer tissues than in adjacent non-cancer tissues. In addition, significantly higher concentrations of 8-OHdG, iNOS, NFkappaB, Mcl-1 and IAP were detected in patients infected with H pylori compared with patients who were not infected with H pylori. Furthermore, 8-OHdG, iNOS, NFkappaB, Mcl-1 and IAP concentrations were significantly higher in stage 3 and 4 patients than in stage 1 and 2 patients.
conclusionChronic H pylori infection induces iNOS expression and subsequent DNA damage as well as enhances anti-apoptosis signal transduction. This sequence of events supports the hypothesis that oxygen-free radical-mediated damage due to H pylori plays a pivotal role in the development of gastric carcinoma in patients with chronic gastritis.
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