ArticleHistochemistry and cell biology2004
Alteration of podocytes in a murine model of crescentic glomerulonephritis.
Article in Histochemistry and cell biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Protective Role of Nrf2 in Renal Disease.Antioxidants (Basel, Switzerland) · 2020Review
- Urinary podocyte and TGF-β1 mRNA as markers for disease activity and progression in anti-glomerular basement membrane nephritis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2017Article
- Are podocytes motile?Pflugers Archiv : European journal of physiology · 2017Review
- Formation of tight junctions between neighboring podocytes is an early ultrastructural feature in experimental crescentic glomerulonephritis.International journal of nephrology and renovascular disease · 2016Article
- Nuclear Factor Erythroid 2-Related Factor 2 Drives Podocyte-Specific Expression of Peroxisome Proliferator-Activated Receptor γ Essential for Resistance to Crescentic GN.Journal of the American Society of Nephrology : JASN · 2016Article
- Sirtuin1 Maintains Actin Cytoskeleton by Deacetylation of Cortactin in Injured Podocytes.Journal of the American Society of Nephrology : JASN · 2015Article
- Ultrastructural pathological features of unilateral renal artery stenosis in the rats.International journal of clinical and experimental pathology · 2015Article
- Pathogenetic role of glomerular CXCL13 expression in lupus nephritis.Clinical and experimental immunology · 2014Article
- Update on crescentic glomerulonephritis.Seminars in immunopathology · 2014Review
- Two-photon microscopy reveals stationary podocytes in living zebrafish larvae.Journal of the American Society of Nephrology : JASN · 2014Article
- Parietal epithelial cell activation marker in early recurrence of FSGS in the transplant.Clinical journal of the American Society of Nephrology : CJASN · 2012Article
- Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis.Nature medicine · 2011Article
- Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?The Journal of clinical investigation · 2011Review
- The monocyte chemoattractant protein-1/cognate CC chemokine receptor 2 system affects cell motility in cultured human podocytes.The American journal of pathology · 2007Article
- Recent progress in histochemistry and cell biology: the state of the art 2005.Histochemistry and cell biology · 2005Review
- News and views in Histochemistry and Cell Biology.Histochemistry and cell biology · 2004Review
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent observations suggest a central role of podocytes in crescent formation. In experimental glomerulonephritis podocytes disrupt the parietal epithelial layer and attach on its basement membrane, thus forming bridges between the tuft and Bowman's capsule, and they are a major constituent of crescents. In order to explain these findings we hypothesize that inflammation triggers motility in podocytes. In the present study we asked whether podocytes display alterations which suggest a migratory behavior in glomerulonephritis. Glomerulonephritis was induced in mice by injection of a rabbit serum against the glomerular basement membrane. The kidneys were perfusion-fixed 6 days later and examined by light and electron microscopy as well as by immunohistochemistry. In glomerulonephritis the apical cytoplasm of podocytes displayed numerous actin-containing microprotrusions. Cortactin, a protein involved in the regulation of actin polymerization, was predominantly expressed in foot processes of podocytes in control mice. It was redistributed to the cell body in glomerulonephritis. In untreated mice betal-integrin was restricted to the foot processes. In glomerulonephritis it was additionally found in the cytoplasm and in the apical cell membrane. Recycling of integrins is a crucial event in initiation of cell migration. ICAM-1 and CD44, the ligation of which induces migratory behaviors, were absent from healthy podocytes but expressed by some podocytes in glomerulonephritis. Thus, in glomerulonephritis podocytes display some characteristic features of migrating cells. This might explain their ability to break through the parietal epithelium and to become a constituent of early crescents.
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