ArticleNature immunology2004
B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5.
Article in Nature immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 109 citations in OpenAlex.
- Intra- and interchromosomal contact mapping reveals the Igh locus has extensive conformational heterogeneity and interacts with B-lineage genes.Cell reports · 2023Article
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- Chromatin mutations in pediatric high grade gliomas.Frontiers in oncology · 2022Review
- Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins.The Journal of cell biology · 2015Article
- Localized DNA demethylation at recombination intermediates during immunoglobulin heavy chain gene assembly.PLoS biology · 2013Article
- Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions.Nature immunology · 2012Article
- Chromatin remodeling, DNA damage repair and aging.Current genomics · 2012Article
- CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis.The Journal of clinical investigation · 2012Article
- FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination.The Journal of experimental medicine · 2012Article
- Histone acetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediated transcriptional activity.The Journal of biological chemistry · 2011Article
- Recombination centres and the orchestration of V(D)J recombination.Nature reviews. Immunology · 2011Review
- Epigenetic control of recombination in the immune system.Seminars in immunology · 2010Review
- The mouse immunoglobulin heavy chain V-D intergenic sequence contains insulators that may regulate ordered V(D)J recombination.The Journal of biological chemistry · 2010Article
- Review
- A 220-nucleotide deletion of the intronic enhancer reveals an epigenetic hierarchy in immunoglobulin heavy chain locus activation.The Journal of experimental medicine · 2009Article
- Temporal and spatial regulation of V(D)J recombination: interactions of extrinsic factors with the RAG complex.Advances in experimental medicine and biology · 2009Review
- Pax5 and linker histone H1 coordinate DNA methylation and histone modifications in the 3' regulatory region of the immunoglobulin heavy chain locus.Molecular and cellular biology · 2008Article
- Activation of 12/23-RSS-dependent RAG cleavage by hSWI/SNF complex in the absence of transcription.Molecular cell · 2008Article
- Functional analysis of histone methyltransferase g9a in B and T lymphocytes.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Reciprocal patterns of methylation of H3K36 and H3K27 on proximal vs. distal IgVH genes are modulated by IL-7 and Pax5.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Immunoglobulin heavy chain rearrangement (V(H)-to-DJ(H)) occurs only in B cells, suggesting it is inhibited in other lineages. Here we found that in the mouse V(H) locus, methylation of lysine 9 on histone H3 (H3-K9), a mark of inactive chromatin, was present in non-B lineage cells but was absent in B cells. As others have shown that H3-K9 methylation can inhibit V(D)J recombination on engineered substrates, our data support the idea that H3-K9 methylation inhibits endogenous V(H)-to-DJ(H) recombination. We also show that Pax5, a transcription factor required for B cell commitment, is necessary and sufficient for the removal of H3-K9 methylation in the V(H) locus and provide evidence that one function of Pax5 is to remove this inhibitory modification by a mechanism of histone exchange, thus allowing B cell-specific V(H)-to-DJ(H) recombination.
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