ArticleOncogene2004
ATM activity contributes to the tumor-suppressing functions of p14ARF.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Inhibitory effect of Korean Red Ginseng extract on DNA damage response and apoptosis inJournal of ginseng research · 2020Article
- Foxp1 Regulates the Proliferation of Hair Follicle Stem Cells in Response to Oxidative Stress during Hair Cycling.PloS one · 2015Article
- MKK7 and ARF: new players in the DNA damage response scenery.Cell cycle (Georgetown, Tex.) · 2014Article
- Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer.Nature cell biology · 2013Article
- Propagation of human prostate cancer stem-like cells occurs through EGFR-mediated ERK activation.PloS one · 2013Article
- Article
- ARF triggers cell G1 arrest by a P53 independent ERK pathway.Molecular and cellular biochemistry · 2011Article
- PTEN inhibits BMI1 function independently of its phosphatase activity.Molecular cancer · 2009Article
- Tumour suppression by p53: a role for the DNA damage response?Nature reviews. Cancer · 2009Review
- Cooperative effect of p21Cip1/WAF-1 and 14-3-3sigma on cell cycle arrest and apoptosis induction by p14ARF.Oncogene · 2008Article
- hAda3 degradation by papillomavirus type 16 E6 correlates with abrogation of the p14ARF-p53 pathway and efficient immortalization of human mammary epithelial cells.Journal of virology · 2008Article
- Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.The Journal of experimental medicine · 2006Article
- Identification of an ataxia telangiectasia-mutated protein mediated surveillance system to regulate Bcl-2 overexpression.Oncogene · 2006Article
- p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress.Molecular and cellular biology · 2006Article
- ERK activity facilitates activation of the S-phase DNA damage checkpoint by modulating ATR function.Oncogene · 2006Article
- Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor.The EMBO journal · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
P14/p19ARF (ARF) plays a major role in the activation of p53 by oncogenic signals. The biochemical basis of this has not been fully elucidated. We report here that forced expression of p14ARF enhances phosphorylation of p53 serine 15 (p53S15) in NIH3T3, IMR90 and MCF7 cells. Ectopic expression of the oncogenes c-myc, E2F1 and E1A, all of which activate p53 at least partially via ARF, lead to p53S15 phosphorylation in IMR90 cells. In addition, ectopic expression of p53 also results in p53S15 phosphorylation, suggesting that this is a common event in the ARF-p53 tumor suppression system. Furthermore, p53-, p14ARF-, c-myc- and E2F1-, but not E1A-, induced p53S15 phosphorylation was substantially reduced in AT fibroblasts (GM05823). Downregulation of ATM in MCF7 cells using RNA interference (RNAi) technology significantly attenuated p14ARF- and p53-induced phosphorylation of p53S15. Ectopically expressed ARF in NIH3T3 cells induced ATM nuclear foci and activated ATM kinase. Functionally, ectopic expression of p14ARF and c-myc inhibited the proliferation of IMR90 but not ATM null GM05823 cells, and p14ARF-induced inhibition of MCF7 cell proliferation was significantly attenuated by downregulation of ATM by RNAi. Taken together, these data show a functional role for ATM in ARF-mediated tumor suppression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.