ReviewImmunologic research2004
Manipulation of iron to determine survival: competition between host and pathogen.
Review in Immunologic research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- Iron Regulatory Protein 1 Inhibits Ferritin Translation Responding to OsHV-1 Infection in Ark Clams,Cells · 2022Article
- Some nontoxic metal-based drugs for selected prevalent tropical pathogenic diseases.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2017Review
- Map-based comparative genomic analysis of virulent haemophilus parasuis serovars 4 and 5.Journal of genomics · 2015Article
- Coordination chemistry of bacterial metal transport and sensing.Chemical reviews · 2009Review
- Cloning and characterization of a novel periplasmic heme-transport protein from the human pathogen Pseudomonas aeruginosa.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron is an essential nutrient that can determine cellular survival. Many organisms have evolved sophisticated mechanisms for iron uptake and transport to support their growth. The dual dependence on iron of both the host and invading pathogen initiates a competition for this nutrient following infection. Microorganisms have developed various strategies to acquire iron from the host. These are counter-balanced by an iron-withholding strategy that the host deploys as part of its defense system. This strategy, involving many iron-regulatory proteins, mediates iron depletion at the mucosal surfaces, in the extracellular environment, and within the cells. Iron is sequestered into storage by the host in order to deprive the pathogens of this factor and to prevent their proliferation. This system can be compromised. In particular, new evidence is emerging that suggests that viruses are able to specifically target and regulate proteins involved in iron homeostasis. This review focuses on the procedures employed by the host and viruses to regulate iron as a means of defense and survival, respectively.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.