Trial reportProceedings of the National Academy of Sciences of the United States of America2004
Biological activity of nitric oxide in the plasmatic compartment.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 161 citations in OpenAlex.
- Effects of Aged Stored Autologous Red Blood Cells on Human Endothelial Function.American journal of respiratory and critical care medicine · 2015Trial
- S-nitrosocysteamine-functionalised porous graphene oxide nanosheets as nitric oxide delivery vehicles for cardiovascular applications.Redox biology · 2024Article
- Plasma eNOS Concentration in Healthy Pregnancy and in Hypertensive Disorders of Pregnancy: Evidence of Reduced Concentrations in Pre-Eclampsia from Two Independent Studies.Diseases (Basel, Switzerland) · 2023Article
- NO Addition during Gas Oxygenation Reduces Liver and Kidney Injury during Prolonged Cardiopulmonary Bypass.Pathophysiology : the official journal of the International Society for Pathophysiology · 2023Article
- Article
- Tri-iodide and vanadium chloride based chemiluminescent methods for quantification of nitrogen oxides.Nitric oxide : biology and chemistry · 2022Article
- HGT in the human and skin commensalProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Formal guidelines: management of acute respiratory distress syndrome.Annals of intensive care · 2019Review
- Effect of plasma processing and storage on microparticle abundance, nitric oxide scavenging, and vasoactivity.Transfusion · 2019Article
- Endothelial dysfunction inhibits the ability of haptoglobin to prevent hemoglobin-induced hypertension.American journal of physiology. Heart and circulatory physiology · 2017Article
- Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning.Science translational medicine · 2016Article
- Exposure of Stored Packed Erythrocytes to Nitric Oxide Prevents Transfusion-associated Pulmonary Hypertension.Anesthesiology · 2016Article
- Postprandial lipids accelerate and redirect nitric oxide consumption in plasma.Nitric oxide : biology and chemistry · 2016Article
- Increased consumption and vasodilatory effect of nitrite during exercise.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Percutaneous Mitral Valve Repair in Mitral Regurgitation Reduces Cell-Free Hemoglobin and Improves Endothelial Function.PloS one · 2016Observational
- Cell-free plasma hemoglobin removal by dialyzers with various permeability profiles.Scientific reports · 2015Article
- Prooxidative effects of aspartame on antioxidant defense status in erythrocytes of rats.Journal of biosciences · 2014Article
- Role of blood and vascular smooth muscle in the vasoactivity of nitrite.American journal of physiology. Heart and circulatory physiology · 2014Article
- Transfusion of older stored blood worsens outcomes in canines depending on the presence and severity of pneumonia.Transfusion · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There exist reaction products of nitric oxide (NO) with blood that conserve its bioactivity and transduce an endocrine vasomotor function under certain conditions. Although S-nitrosated albumin has been considered the major species subserving this activity, recent data suggest that additional NO species, such as nitrite, nitrated lipids, N-nitrosamine, and iron-nitrosyl complexes, may contribute. We therefore examined the end products of NO reactions in plasma and blood in vitro and in vivo by using reductive chemiluminescent assays and electron paramagnetic resonance spectroscopy. We found that NO complexes in plasma previously considered to be S-nitrosated albumin were <10 nM after elimination of nitrite and were mercury-stable, consistent with iron-nitrosyl or N-nitrosamine complex. During clinical NO gas inhalation protocols or in vitro NO donor treatment of human plasma, S-nitroso-albumin did not form with NO exposure <2 microM, but plasma methemoglobin was detectable by paramagnetic resonance spectroscopy. Consistent with this formation of methemoglobin, human plasma was found to consume approximately 2 microM NO at a rate equivalent to that of hemoglobin. This NO consumption was mediated by the reaction of NO with plasma haptoglobin-hemoglobin complexes and limited slower reaction pathways required for S-nitrosation. These data suggest that high-affinity, metal-based reactions in plasma with the haptoglobin-hemoglobin complex modulate plasmatic NO reaction products and limit S-nitrosation at low NO flux. The studies further suggest that alternative NO reaction end products in plasma, such as nitrite, N-nitrosamines, iron-nitrosyls, and nitrated lipids, should be evaluated in blood NO transport along the vasculature.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.