ArticleRheumatology international2005
Vascular endothelial and basic fibroblast growth factor serum levels in patients with Behçet's disease.
Article in Rheumatology international, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Association of Circulating Vascular Endothelial Growth Factor Levels With Autoimmune Diseases: A Systematic Review and Meta-Analysis.Frontiers in immunology · 2021Pooled it
- Circulating VEGF levels and genetic polymorphisms in Behçet's disease: a meta-analysis.Journal of rheumatic diseases · 2025Article
- Relationship between the higher inflammatory cytokines level in the aqueous humor of Fuchs uveitis syndrome and the presence of cataract.BMC ophthalmology · 2021Article
- Aqueous humor IL-8, IL-10, and VEGF levels in Fuchs' uveitis syndrome and Behçet's uveitis.International ophthalmology · 2019Article
- Lessons of the month 2: A case of Behçet's disease: 70% have ophthalmic involvement.Clinical medicine (London, England) · 2019Article
- High levels of endothelial progenitor cells and circulating endothelial cells in patients with Behçet's disease and their relationship to disease activity.Anais brasileiros de dermatologia · 2019Article
- The Evaluation of the Relationship between sTREM-1, VEGF-B, and VEGF Gene Expression Levels with Disease Activity of Behçet's Patients.Disease markers · 2018Article
- Association of Rho-kinase 1 (ROCK1) gene polymorphisms with Behçet's disease.Molecular diagnosis & therapy · 2014Article
- Serum prolidase enzyme activity and oxidative status in patients with Behçet's disease.Redox report : communications in free radical research · 2014Article
- The relationship between serum levels of angiogenin, bFGF, VEGF, and ocular involvement in patients with Behçet's disease.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2013Article
- Behçet's Disease as a Model of Venous Thrombosis.The open cardiovascular medicine journal · 2010Article
- Vascular endothelial growth factor and carotid intima-media thickness in patients with Behçet's disease.Clinical rheumatology · 2008Article
- Vascular endothelial growth factor (VEGF) in autoimmune diseases.Journal of clinical immunology · 2007Review
- Characteristics of Macular Edema in Behcet Disease after Intravitreal Bevacizumab Injection.Journal of ophthalmic & vision researchArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Behçet's disease (BD) is a systemic vasculitis of unknown aetiology. Its pathogenesis is related to endothelial cell dysfunction, humoral immune defects, and immune system dysregulation. The aim of this study was to investigate the possible role of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in the pathogenesis of BD. We also investigated whether disease activity, age, or duration of BD correlates with VEGF and bFGF. We studied 33 patients and 20 healthy controls. Vascular endothelial growth factor and bFGF serum levels were measured by enzyme-linked immunosorbent assay. We measured acute phase reactants, including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). The mean serum VEGF level was significantly higher in patients with BD (398.8+/-222.2 pg/ml) than the control group (193.0+/-122.4 pg/ml) (P=0.002). The levels were similar in both active and inactive BD (P=0.675) but did not correlate with disease duration, CRP, ESR, or age (P>0.05 for each). The bFGF was below detection limits in 18 of 33 patients with BD and ten of 20 controls, and its mean serum level was higher in BD patients (42.4+/-76.9 pg/ml) than controls (29.0+/-9.1 pg/ml), but this difference was not statistically significant (P=0.232). The bFGF levels were similar in both active and inactive BD (P=0.09) and, in patients, correlated with disease duration and CRP (r=0.58, P=0.02; r=-0.57, P=0.02, respectively) but not with ESR or age (P>0.05 for each). Vascular endothelial growth factor may be more important in the pathogenesis of BD than bFGF. Neither growth factor is an activity criterion or inflammatory marker in BD.
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