ArticleGenome research2004
The binding sites for the chromatin insulator protein CTCF map to DNA methylation-free domains genome-wide.
Article in Genome research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
72 citing papers in PubMed, 130 citations in OpenAlex.
- Gene regulatory complexes: their role and regulation across normal and malignant hematopoiesis.Experimental hematology · 2025Review
- The Dynamic Regulation of G-Quadruplex DNA Structures by Cytosine Methylation.International journal of molecular sciences · 2022Review
- CTCF as a regulator of alternative splicing: new tricks for an old player.Nucleic acids research · 2021Review
- Regulation of the Methylation and Expression Levels of the BMPR2 Gene by SIN3a as a Novel Therapeutic Mechanism in Pulmonary Arterial Hypertension.Circulation · 2021Article
- Application of 5-Methylcytosine DNA Glycosylase to the Quantitative Analysis of DNA Methylation.International journal of molecular sciences · 2021Article
- Article
- DNA methylation QTL analysis identifies new regulators of human longevity.Human molecular genetics · 2020Article
- Enhancer functions in three dimensions: beyond the flat world perspective.F1000Research · 2018Review
- A streamlined method for analysing genome-wide DNA methylation patterns from low amounts of FFPE DNA.BMC medical genomics · 2017Article
- CTCF and CohesinSA-1 Mark Active Promoters and Boundaries of Repressive Chromatin Domains in Primary Human Erythroid Cells.PloS one · 2016Article
- Article
- Alterations of histone modifications at the senescence-associated gene HvS40 in barley during senescence.Plant molecular biology · 2015Article
- Integrated analyses to reconstruct microRNA-mediated regulatory networks in mouse liver using high-throughput profiling.BMC genomics · 2015Article
- Architectural proteins: regulators of 3D genome organization in cell fate.Trends in cell biology · 2014Review
- Article
- Effects of cytosine methylation on transcription factor binding sites.BMC genomics · 2014Article
- Article
- Induced DNA demethylation can reshape chromatin topology at the IGF2-H19 locus.Nucleic acids research · 2013Article
- CCCTC-binding factor controls its own nuclear transport via regulating the expression of importin 13.Molecules and cells · 2013Article
- Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity.PLoS genetics · 2013Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
Abstract
All known vertebrate chromatin insulators interact with the highly conserved, multivalent 11-zinc finger nuclear factor CTCF to demarcate expression domains by blocking enhancer or silencer signals in a position-dependent manner. Recent observations document that the properties of CTCF include reading and propagating the epigenetic state of the differentially methylated H19 imprinting control region. To assess whether these findings may reflect a universal role for CTCF targets, we identified more than 200 new CTCF target sites by generating DNA microarrays of clones derived from chromatin-immunopurified (ChIP) DNA followed by ChIP-on-chip hybridization analysis. Target sites include not only known loci involved in multiple cellular functions, such as metabolism, neurogenesis, growth, apoptosis, and signalling, but potentially also heterochromatic sequences. Using a novel insulator trapping assay, we also show that the majority of these targets manifest insulator functions with a continuous distribution of stringency. As these targets are generally DNA methylation-free as determined by antibodies against 5-methylcytidine and a methyl-binding protein (MBD2), a CTCF-based network correlates with genome-wide epigenetic states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.