ArticleAnnals of the rheumatic diseases2005
Inhibition of TNF alpha during maturation of dendritic cells results in the development of semi-mature cells: a potential mechanism for the beneficial effects of TNF alpha blockade in rheumatoid arthritis.
Article in Annals of the rheumatic diseases, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 59 citations in OpenAlex.
- Amlodipine as an immunomodulator to enhance dendritic cell activation in cancer therapy with tumor-associated antigens.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Molecular Signatures of Dendritic Cell Activation upon TNF Stimulation: A Multi-Omics Study in Rheumatoid Arthritis.International journal of molecular sciences · 2025Article
- Impaired Proliferation of CD8Journal of immunology research · 2024Article
- The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2.Cell death & disease · 2023Article
- CC chemokines and receptors in osteoarthritis: new insights and potential targets.Arthritis research & therapy · 2023Review
- Immune-regulating strategy against rheumatoid arthritis by inducing tolerogenic dendritic cells with modified zinc peroxide nanoparticles.Journal of nanobiotechnology · 2022Article
- PD-L1- and calcitriol-dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease.JCI insight · 2019Article
- An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium.Cytokine · 2017Article
- Future therapeutic targets in rheumatoid arthritis?Seminars in immunopathology · 2017Review
- Collagen I-induced dendritic cells activation is regulated by TNF-alpha production through down-regulation of IRF4.Journal of biosciences · 2015Article
- Dendritic cell maturation and survival are differentially regulated by TNFR1 and TNFR2.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- The effect of cyclic mechanical strain on activation of dendritic cells cultured on adhesive substrates.Biomaterials · 2013Article
- Dendritic cells as targets for therapy in rheumatoid arthritis.Nature reviews. Rheumatology · 2009Review
- Etanercept impairs maturation of human monocyte-derived dendritic cells by inhibiting the autocrine TNFalpha-mediated signaling.Inflammation · 2009Article
- TNFalpha blockade prevents the development of inflammatory bowel disease in HLA-B27 transgenic rats.Journal of cellular and molecular medicine · 2009Article
- Circulating levels of the chemokine CCL18 but not CXCL16 are elevated and correlate with disease activity in rheumatoid arthritis.Annals of the rheumatic diseases · 2007Article
- Expression and regulation of CCL18 in synovial fluid neutrophils of patients with rheumatoid arthritis.Arthritis research & therapy · 2007Article
- Novel insights in the regulation of CCL18 secretion by monocytes and dendritic cells via cytokines, toll-like receptors and rheumatoid synovial fluid.BMC immunology · 2006Article
- Dendritic cells, Fc{gamma} receptors, and Toll-like receptors: potential allies in the battle against rheumatoid arthritis.Annals of the rheumatic diseases · 2005Review
- Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes.Journal of leukocyte biology · 2005Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDendritic cells orchestrate pivotal immunological processes mediated by the production of cytokines and chemokines.
objectiveTo assess whether neutralisation of tumour necrosis factor alpha (TNF alpha) during maturation of dendritic cells affects their phenotype and behaviour, which might explain the beneficial effects of TNF alpha neutralisation in rheumatoid arthritis.
methodsImmature and fully matured dendritic cells were cultured from blood monocytes from patients with rheumatoid arthritis and healthy controls following standardised protocols. TNF alpha was neutralised by addition of the p55 soluble TNF alpha receptor, PEGsTNFRI. The effect of TNF alpha neutralisation on the phenotype (CD14, CD16, CD32, CD64, CD80, CD83, CD86, and MHC) of dendritic cells was investigated by flow cytometry. Expression of chemokines (CCL17, CCL18, CCL19, CCL22, CCL3, and CXCL8) and production of IL1 beta and IL6 during dendritic cell differentiation and maturation were examined.
resultsNeutralisation of TNF alpha during the differentiation and maturation of dendritic cells did not result in an altered dendritic cell phenotype in the rheumatoid patients or the healthy controls. In contrast, the expression of CCL17, CCL18, CCL19, CCL22, CCL3, and CXCL8 by dendritic cells was significantly reduced when TNF alpha activity was inhibited during lipopolysaccharide triggered dendritic cell maturation. The production of IL1 beta and IL6 by mature dendritic cells was inhibited by PEGsTNFRI.
conclusionsInhibition of TNF alpha activity during dendritic cell maturation leads to the development of semi-mature cells. These data suggest a novel pathway by which the neutralisation of TNF alpha might exert its therapeutic effects.
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