ArticleNeoplasia (New York, N.Y.)
Human cytomegalovirus infection of tumor cells downregulates NCAM (CD56): a novel mechanism for virus-induced tumor invasiveness.
Article in Neoplasia (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- CD56 on immune and tumor cells: what is known and beyond?Clinical and experimental immunology · 2025Review
- Extramedullary Multiple Myeloma: A Patient-Focused Review of the Pathogenesis of Bone Marrow Escape.World journal of oncology · 2022Article
- Transcriptomic Changes ofFrontiers in microbiology · 2022Article
- Splice-Junction-Based Mapping of Alternative Isoforms in the Human Proteome.Cell reports · 2019Article
- Article
- Review
- Flow cytometric aberrancies in plasma cell myeloma and MGUS - correlation with laboratory parameters.Cytometry. Part B, Clinical cytometry · 2018Article
- How does cytomegalovirus factor into diseases of aging and vaccine responses, and by what mechanisms?GeroScience · 2017Article
- Deficiency of GDNF Receptor GFRα1 in Alzheimer's Neurons Results in Neuronal Death.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Article
- Human cytomegalovirus infection enhances NF-κB/p65 signaling in inflammatory breast cancer patients.PloS one · 2013Article
- Is human cytomegalovirus a target in cancer therapy?Oncotarget · 2011Review
- Is HCMV a tumor promoter?Virus research · 2011Review
- Oncomodulation by human cytomegalovirus: novel clinical findings open new roads.Medical microbiology and immunology · 2011Review
- The story of human cytomegalovirus and cancer: increasing evidence and open questions.Neoplasia (New York, N.Y.) · 2009Review
- Lack of CD56 expression on myeloma cells is not a marker for poor prognosis in patients treated by high-dose chemotherapy and is associated with translocation t(11;14).Bone marrow transplantation · 2007Article
- Valproic acid inhibits adhesion of vincristine- and cisplatin-resistant neuroblastoma tumour cells to endothelium.British journal of cancer · 2007Article
- Human cytomegalovirus infection alters PC3 prostate carcinoma cell adhesion to endothelial cells and extracellular matrix.Neoplasia (New York, N.Y.) · 2006Article
- [Research in urologic university clinics. Assessment of current status and perspectives].Der Urologe. Ausg. A · 2006Article
- Lymphoma cell apoptosis in the liver induced by distant murine cytomegalovirus infection.Journal of virology · 2006Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathologic data indicate that human cytomegalovirus (HCMV) infection might be associated with the pathogenesis of several human malignancies. However, no definitive evidence of a causal link between HCMV infection and cancer dissemination has been established to date. This study describes the modulation of the invasive behavior of NCAM-expressing tumor cell lines by HCMV. Neuroblastoma (NB) cells, persistently infected with the HCMV strain AD169 (UKF-NB-4AD169 and MHH-NB-11AD169), were added to endothelial cell monolayers and adhesion and penetration kinetics were measured. The 140- and 180-kDa isoforms of the adhesion receptor NCAM were evaluated by flow cytometry, Western blot, and reverse transcription-polymerase chain reaction (RT-PCR). The relevance of NCAM for tumor cell binding was proven by treating NB with NCAM antisense oligonucleotides or NCAM transfection. HCMV infection profoundly increased the number of adherent and penetrated NB, compared to controls. Surface expression of NCAM was significantly lower on UKF-NB-4AD169 and MHH-NB-11AD169, compared to mock-infected cells. Western-blot and RT-PCR demonstrated reduced protein and RNA levels of the 140- and 180-kDa isoform. An inverse correlation between NCAM expression and adhesion capacity of NB has been shown by antisense and transfection experiments. We conclude that HCMV infection leads to downregulation of NCAM receptors, which is associated with enhanced tumor cell invasiveness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.