ArticleBritish journal of clinical pharmacology2004
Plasma concentrations during naltrexone implant treatment of opiate-dependent patients.
Article in British journal of clinical pharmacology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00204243 (Naltrexone Implants Compared to Methadone Maintenance Treatment), which is not on this map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Naltrexone Implants Compared to Methadone Maintenance Treatment (MMT) Among Inmates About to be Released From Prison - a Randomized Controlled Trial
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Naltrexone depot formulations for opioid and alcohol dependence: a systematic review.CNS neuroscience & therapeutics · 2011Pooled it
- Sustained-release naltrexone for opioid dependence.The Cochrane database of systematic reviews · 2008Pooled it
- Naltrexone Implant for Opioid Use Disorder.Neurology international · 2021Review
- Management of Sedation and Analgesia in Critically Ill Patients Receiving Long-Acting Naltrexone Therapy for Opioid Use Disorder.Annals of the American Thoracic Society · 2020Article
- Opioid Addiction: Social Problems Associated and Implications of Both Current and Possible Future Treatments, including Polymeric Therapeutics for Giving Up the Habit of Opioid Consumption.BioMed research international · 2017Review
- Injectable and implantable sustained release naltrexone in the treatment of opioid addiction.British journal of clinical pharmacology · 2014Review
- Naltrexone-induced Nicolau syndrome masquerading as cutaneous abscess.BMJ case reports · 2012Article
- Advances in opioid antagonist treatment for opioid addiction.The Psychiatric clinics of North America · 2012Article
- Pharmacological enhancement of naltrexone treatment for opioid dependence: a review.Substance abuse and rehabilitation · 2011Article
- Selective review and commentary on emerging pharmacotherapies for opioid addiction.Substance abuse and rehabilitation · 2011Review
- Cholestasis and endogenous opioids: liver disease and exogenous opioid pharmacokinetics.Clinical pharmacokinetics · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo evaluate individual variations in plasma concentrations over time in patients with naltrexone implants.
methodsTen opioid-dependent patients received up to four implants. Plasma samples were collected regularly for the analyses of naltrexone and the metabolite beta-naltrexol.
resultsThe median naltrexone C(max) was 12.3 (range 5.8-22.1) ng ml(-1), the median T(max) was 1 day (range 3 h to 35 days), and the median length of time that plasma concentrations were above 1 ng ml(-1) was 55 (range 30-80) days. Two patients reported heroin use without experiencing any effect. Tissue reactions were recorded in two patients after repeated implantation.
conclusionMarked individual and intraindividual variations in naltrexone concentrations were observed. Further studies should be performed to evaluate the need for therapeutic drug monitoring during naltrexone implant treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.