ArticleProceedings. Biological sciences2004
Allele excess at neutrally evolving microsatellites and the implications for tests of neutrality.
Article in Proceedings. Biological sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Genome sequencing and resequencing identified three horizontal gene transfers and uncovered the genetic mechanism on the intraspecies adaptive evolution ofFrontiers in plant science · 2022Article
- Massive variation of short tandem repeats with functional consequences across strains ofGenome research · 2018Article
- Coalescent tree imbalance and a simple test for selective sweeps based on microsatellite variation.PLoS computational biology · 2013Article
- Article
- Purifying Selection Bias against Microsatellites in Gene Rich Segmental Duplications in the Rice Genome.International journal of evolutionary biology · 2012Article
- Genetic structure of red-handed howler monkey populations in the fragmented landscape of Eastern Brazilian Amazonia.Genetics and molecular biology · 2010Article
- Spatio-temporal population structuring and genetic diversity retention in depleted Atlantic bluefin tuna of the Mediterranean Sea.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Population diversity and antibody selective pressure to Plasmodium falciparum MSP1 block2 locus in an African malaria-endemic setting.BMC microbiology · 2009Article
- Article
- Sampling genetic diversity in the sympatrically and allopatrically speciating Midas cichlid species complex over a 16 year time series.BMC evolutionary biology · 2007Article
- Evolutionary adaptation to high altitude: a view from in utero.American journal of human biology : the official journal of the Human Biology CouncilReview
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3 authors.
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Abstract
Skews in the observed allele-frequency spectrum are frequently viewed as an indication of non-neutral evolution. Recent surveys of microsatellite variability have used an excess of alleles as a statistical approach to infer positive selection. Using neutral coalescent simulations we demonstrate that the mean numbers of alleles expected under the stepwise-mutation model and infinite-allele model deviate from the observed numbers of alleles. The magnitude of this difference is dependent on the sample size, mutation rates (theta-values) and observed gene diversities. Moreover, we show that the number of observed alleles differs among loci with the same observed gene diversity but different mutation rates (theta-values). We propose that a reliable test statistic based on allele excess must determine the confidence interval by computer simulations conditional on the observed gene diversity and theta-values. As the latter are notoriously difficult to obtain for experimental data, we suggest that other statistics, such as lnRV, may be better suited to the identification of microsatellite loci subject to selection.
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