ArticleProceedings. Biological sciences2004
Feedback control of T-cell receptor activation.
Article in Proceedings. Biological sciences, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Mathematical models of TCR initial triggering.Frontiers in immunology · 2024Review
- Article
- Ultrasensitivity in the Cofilin Signaling Module: A Mechanism for Tuning T Cell Responses.Frontiers in immunology · 2016Review
- Activated PLC-γ1 is catalytically induced at LAT but activated PLC-γ1 is localized at both LAT- and TCR-containing complexes.Cellular signalling · 2014Article
- Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells.eLife · 2013Article
- Low 2-dimensional CD4 T cell receptor affinity for myelin sets in motion delayed response kinetics.PloS one · 2012Article
- Systems biology in immunology: a computational modeling perspective.Annual review of immunology · 2011Review
- Computational analysis of T cell receptor signaling and ligand discrimination--past, present, and future.FEBS letters · 2010Review
- Manipulating antigenic ligand strength to selectively target myelin-reactive CD4+ T cells in EAE.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010Review
- A role for rebinding in rapid and reliable T cell responses to antigen.PLoS computational biology · 2009Article
- A logical model provides insights into T cell receptor signaling.PLoS computational biology · 2007Article
- T-cell activation: A queuing theory analysis at low agonist density.Biophysical journal · 2006Article
- Ligand detection and discrimination by spatial relocalization: A kinase-phosphatase segregation model of TCR activation.Biophysical journal · 2006Article
- Modeling T cell antigen discrimination based on feedback control of digital ERK responses.PLoS biology · 2005Article
- Immunology and mathematics: crossing the divide.Immunology · 2005Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The specificity and sensitivity of T-cell recognition is vital to the immune response. Ligand engagement with the T-cell receptor (TCR) results in the activation of a complex sequence of signalling events, both on the cell membrane and intracellularly. Feedback is an integral part of these signalling pathways, yet is often ignored in standard accounts of T-cell signalling. Here we show, using a mathematical model, that these feedback loops can explain the ability of the TCR to discriminate between ligands with high specificity and sensitivity, as well as provide a mechanism for sustained signalling. The model also explains the recent counter-intuitive observation that endogenous 'null' ligands can significantly enhance T-cell signalling. Finally, the model may provide an archetype for receptor switching based on kinase-phosphatase switches, and thus be of interest to the wider signalling community.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.