ArticleThe Journal of clinical investigation2004
Adaptive cellular immunity in aortic aneurysms: cause, consequence, or context?
Article in The Journal of clinical investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 98 citations in OpenAlex.
- Tomo-seq identifies NINJ1 as a potential target for anti-inflammatory strategy in thoracic aortic dissection.BMC medicine · 2023Article
- The effects of statin therapy on aneurysm size, growth rate, and matrix metalloproteinases-9 levels in patients with aortic aneurysm: a systematic review and meta-analysis.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2023Article
- The Incidence of IgG4-Related and Inflammatory Abdominal Aortic Aneurysm Is Rare in a 101 Patient Cohort.Journal of clinical medicine · 2023Article
- Completing the view - histologic insights from circular AAA specimen including 3D imaging : A methodologic approach towards histologic analysis of circumferential AAA samples.Diagnostic pathology · 2023Article
- Single-Cell Sequencing Analysis and Multiple Machine Learning Methods Identified G0S2 and HPSE as Novel Biomarkers for Abdominal Aortic Aneurysm.Frontiers in immunology · 2022Article
- Common molecular mechanism and immune infiltration patterns of thoracic and abdominal aortic aneurysms.Frontiers in immunology · 2022Article
- Therapeutic effect of allogeneic bone marrow-derived mesenchymal stromal cells on aortic aneurysms.Cell and tissue research · 2021Article
- Abdominal Aortic Aneurysm: Roles of Inflammatory Cells.Frontiers in immunology · 2020Review
- Long noncoding RNAs in key cellular processes involved in aortic aneurysms.Atherosclerosis · 2020Review
- Endothelial retinoblastoma protein reduces abdominal aortic aneurysm development via promoting DHFR/NO pathway-mediated vasoprotection.Molecular and cellular biochemistry · 2019Article
- IL (Interleukin)-33 Suppresses Abdominal Aortic Aneurysm by Enhancing Regulatory T-Cell Expansion and Activity.Arteriosclerosis, thrombosis, and vascular biology · 2019Article
- Montelukast, a Cysteinyl Leukotriene Receptor 1 Antagonist, Induces M2 Macrophage Polarization and Inhibits Murine Aortic Aneurysm Formation.BioMed research international · 2019Article
- Vessel wall morphology is equivalent for different artery types and localizations of advanced human aneurysms.Histochemistry and cell biology · 2017Article
- miRNA‑504 inhibits p53‑dependent vascular smooth muscle cell apoptosis and may prevent aneurysm formation.Molecular medicine reports · 2017Article
- Cell Based Therapeutic Approach in Vascular Surgery: Application and Review.Open medicine (Warsaw, Poland) · 2017Article
- Elevated Adiponectin Levels Suppress Perivascular and Aortic Inflammation and Prevent AngII-induced Advanced Abdominal Aortic Aneurysms.Scientific reports · 2016Article
- Activation of the vitamin D receptor selectively interferes with calcineurin-mediated inflammation: a clinical evaluation in the abdominal aortic aneurysm.Laboratory investigation; a journal of technical methods and pathology · 2016Article
- Andrographolide Ameliorates Abdominal Aortic Aneurysm Progression by Inhibiting Inflammatory Cell Infiltration through Downregulation of Cytokine and Integrin Expression.The Journal of pharmacology and experimental therapeutics · 2016Article
- Induction of continuous expanding infrarenal aortic aneurysms in a large porcine animal model.Annals of medicine and surgery (2012) · 2015Article
- Adult vascular wall resident multipotent vascular stem cells, matrix metalloproteinases, and arterial aneurysms.Stem cells international · 2015Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Abdominal aortic aneurysms are common and life threatening. Although CD4(+) T cells are abundant in aneurysm tissue, their role in disease progression remains unclear. A new study shows that mouse aortic allografts placed in animals lacking IFN-gamma receptors develop a Th2 inflammatory response with aortic aneurysms, whereas Th1 responses promote intimal hyperplasia. It is expected that these surprising findings will stimulate further efforts to clarify whether adaptive cellular immunity in aneurysm disease is detrimental or potentially beneficial.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.