ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2004
Nuclear organization of centromeric domains is not perturbed by inhibition of histone deacetylases.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 58 citations in OpenAlex.
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- The Genomic Health of Human Pluripotent Stem Cells: Genomic Instability and the Consequences on Nuclear Organization.Frontiers in genetics · 2018Review
- Inhibitors of Histone Deacetylases Attenuate Noise-Induced Hearing Loss.Journal of the Association for Research in Otolaryngology : JARO · 2016Article
- Dynamic heterogeneity of DNA methylation and hydroxymethylation in embryonic stem cell populations captured by single-cell 3D high-content analysis.Experimental cell research · 2015Article
- Cultivation and differentiation change nuclear localization of chromosome centromeres in human mesenchymal stem cells.PloS one · 2015Article
- Two ways to fold the genome during the cell cycle: insights obtained with chromosome conformation capture.Epigenetics & chromatin · 2014Review
- Differential distribution of HP1 proteins after trichostatin a treatment influences chromosomal stability in HCT116 and WI-38 cells.Cell division · 2014Article
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- Gene positioning and expression.Current opinion in cell biology · 2011Review
- Perinuclear distribution of heterochromatin in developing C. elegans embryos.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2010Article
- Stable morphology, but dynamic internal reorganisation, of interphase human chromosomes in living cells.PloS one · 2010Article
- KRAB zinc-finger proteins localise to novel KAP1-containing foci that are adjacent to PML nuclear bodies.Journal of cell science · 2009Article
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- Histone modifications and nuclear architecture: a review.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2008Review
- Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions.Nature · 2008Article
- Recruitment to the nuclear periphery can alter expression of genes in human cells.PLoS genetics · 2008Article
- Global histone acetylation induces functional genomic reorganization at mammalian nuclear pore complexes.Genes & development · 2008Article
- Porin new light onto chromatin and nuclear organization.Genome biology · 2008Review
- Differentiation-specific association of HP1alpha and HP1beta with chromocentres is correlated with clustering of TIF1beta at these sites.Histochemistry and cell biology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well established that modification of lysines in histone molecules correlates with gene expression and chromatin structure. It is not known whether this operates entirely at a local level, e.g. through the recruitment of specific proteins, or whether histone modifications might impact on more long-range aspects of chromatin organization. There is a distinctive organization of chromatin within the nucleus and the chromatin at the nuclear periphery of mammalian cells appears to be hypoacetylated. Previously it had been suggested that inhibition of histone deacetylases by TSA causes a gross remodeling of nuclear structure, specifically the recruitment of centromeric heterochromatin to the nuclear periphery. Here, we have quantified the nuclear organization of histone modifications and the localization of centromeric domains in human cells before and after TSA treatment. TSA alters the nuclear distribution of histone acetylation, but not that of histone methylation. TSA elevates levels of histone acetylation at the nuclear periphery but we see no alteration in the position of centromeric domains in the nuclei of treated cells. We conclude that the distinctive nuclear localization of centromeric domains is independent of histone acetylation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.